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- Scharer, Orlando D.
- Schärer Lab.
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ERCC1-XPF endonuclease-positioned to cut
- Author(s)
- Scharer, Orlando D.
- Issued Date
- 2017-07
- Citation
- EMBO JOURNAL, v.36, no.14, pp.1993 - 1995
- Abstract
- To counteract damage to our genomes, numerous endo-and exonucleases incise the DNA backbone to remove damaged and aberrant DNA structures. It is imperative that such incisions be very tightly controlled, as unwanted DNA breaks are a key source of genome instability. Two new papers in The EMBO Journal shed light on how the activity of one such nuclease-ERCC1-XPF, an enzyme involved in various DNA repair pathways-is regulated to perform incision in the vicinity of DNA interstrand crosslinks.
- Publisher
- WILEY
- ISSN
- 0261-4189
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