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Granick, Steve
CSLM(Center for Soft and Living Matter) Lab
Research Interests
  • Chemistry, physics, biology, engineering

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Giant capsids from lattice self-assembly of cyclodextrin complexes

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Title
Giant capsids from lattice self-assembly of cyclodextrin complexes
Author
Yang, ShenyuYan, YunHuang, JianbinPetukhov, Andrei V.Kroon-Batenburg, Loes M. J.Drechsler, MarkusZhou, ChengchengTu, MeiGranick, SteveJiang, Lingxiang
Issue Date
201706
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.8, no., pp.15856 -
Abstract
Proteins can readily assemble into rigid, crystalline and functional structures such as viral capsids and bacterial compartments. Despite ongoing advances, it is still a fundamental challenge to design and synthesize protein-mimetic molecules to form crystalline structures. Here we report the lattice self-assembly of cyclodextrin complexes into a variety of capsidlike structures such as lamellae, helical tubes and hollow rhombic dodecahedra. The dodecahedral morphology has not hitherto been observed in self-assembly systems. The tubes can spontaneously encapsulate colloidal particles and liposomes. The dodecahedra and tubes are respectively comparable to and much larger than the largest known virus. In particular, the resemblance to protein assemblies is not limited to morphology but extends to structural rigidity and crystallinity-a well-defined, 2D rhombic lattice of molecular arrangement is strikingly universal for all the observed structures. We propose a simple design rule for the current lattice self-assembly, potentially opening doors for new protein-mimetic materials.
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DOI
http://dx.doi.org/10.1038/ncomms15856
ISSN
2041-1723
Appears in Collections:
SNS_Journal Papers
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