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Park, Sunghoon
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  • Chemical Engineering

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Evaluation of Newly Isolated Klebsiella pneumoniae Strains for the Co-Production of 3-hydroxypropionic acid and 1,3-propanediol from Glycerol

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dc.contributor.authorKo, Yeonjoonull
dc.contributor.authorSeol, Eunheenull
dc.contributor.authorSekar, Balaji Sundaranull
dc.contributor.authorKwon, Seongjinnull
dc.contributor.authorLee, Jarhyeonnull
dc.contributor.authorPark, Sunghoonnull
dc.date.accessioned2017-06-16T04:21:06Z-
dc.date.available2017-06-16T04:21:06Z-
dc.date.created2017-06-14null
dc.date.issued201612null
dc.identifier.citationKSBB JOURNAL, v.31, no.4, pp.246 - 255null
dc.identifier.issn1225-7117null
dc.identifier.urihttp://www.dbpia.co.kr/Journal/ArticleDetail/NODE07091292null
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/22216-
dc.description.abstractCo-production of 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO) was suggested as an innovativestrategy to overcome several limitations occurring in the single production of 3-HP from glycerol. In this study, twonew isolates of Klebsiella pneumoniae, which produce less lipopolysaccharide (LPS) thus considered less pathogenicthan K. pneumoniae DSM 2026, were compared and evaluated for their potential for the co-production of 3-HP and 1,3-PDO. The newly isolated strains showed significantly faster sedimentation rate than DSM, which should be beneficial for downstream processing. Analysis of genome sequences of the isolates confirmed the presence of all genes necessary for glycerol assimilation, 1,3-PDO production and biosynthesis of coenzyme B12. Co-production yield was highest under anaerobic condition while cell growth was highest under aerobic condition. Both strains showed similarly good performance for the co-production although J2B gave the slightly higher co-production yield of 0.80 mol/mol than GSC021 (0.75 mol/mol). The evaluation of the newly developed strains presented here should be useful in designing similar evaluation experiments for other microorganisms.null
dc.languageKORnull
dc.publisher한국생물공학회null
dc.titleEvaluation of Newly Isolated Klebsiella pneumoniae Strains for the Co-Production of 3-hydroxypropionic acid and 1,3-propanediol from Glycerolnull
dc.title.alternative새로이 분리된 Klebsiella pneumoniae 균주들의 글리세롤 기반 3-hydroxypropionic acid 및 1,3-propanediol 동시 생산성 평가null
dc.typeARTICLEnull
dc.identifier.pid3392null
dc.identifier.rimsid28638null
dc.type.rimsAnull
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