This study investigates an innovative method of avoiding brittle fracture at the beam-column connection welds of steel moment frames in earthquakes. The reduced web section (RWS) approach introduces large openings into the web to shift the location of inelasticity away from the connections. The configuration of the openings governs the mode and capacity of inelastic mechanism in the beam. In this paper, experimental results are reported for five RWS specimens that were subjected to quasi-static cyclic loading. Four specimens were designed to develop Mode-A mechanisms; three had a single unique opening at midspan, and one had two openings near the beam-column connections. The other specimen was designed to develop a Mode-B mechanism without having web post buckling (observed in the Phase 1 specimens Shin et al., 2017), which had a wide opening and two brass plates clamped to the web. The application of web openings was successful in achieving the intended inelastic mechanisms; inelastic deformation was due to yielding, buckling, and/or fracture of the webs around the opening(s) and plastic hinging of the T-sections above and below the opening(s). The three specimens with a single opening at midspan exhibited the most stable load-drift responses; the specimens displayed a loss of strength during the 3 or 4% drift cycles (due to local buckling and/or fracture of the webs) and subsequent transition from “full” to “S-shaped” hysteretic loops, but they regained full strength by the end of testing at story drifts up to 7%.