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Myung, Kyungjae
Center for Genomic Integrity
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SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

Author(s)
Lee, DeokjaeAn, JungeunPark, Young-UnLiaw, HungjiunWoodgate, RogerPark, Jun HongMyung, Kyungjae
Issued Date
2017-04
DOI
10.1073/pnas.1701978114
URI
https://scholarworks.unist.ac.kr/handle/201301/21832
Fulltext
http://www.pnas.org/content/early/2017/04/07/1701978114.abstract
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.114, no.17, pp.E3424 - E3433
Abstract
Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the additional function of facilitating rRNA transcription by localizing to the ribosomal DNA (rDNA) promoter in the nucleoli. SHPRH was recruited to the rDNA promoter using its plant homeodomain (PHD), which interacts with histone H3 when the fourth lysine of H3 is not trimethylated. SHPRH enrichment at the rDNA promoter was inhibited by cell starvation, by treatment with actinomycin D or rapamycin, or by depletion of CHD4. SHPRH also physically interacted with the RNA polymerase I complex. Taken together, we provide evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner.
Publisher
NATL ACAD SCIENCES
ISSN
0027-8424
Keyword (Author)
SHPRHrRNA transcriptionhistone H3 methylationmTOR
Keyword
CELL NUCLEAR ANTIGENPOLYMERASE-I TRANSCRIPTIONDNA-DAMAGE RESPONSESGENOMIC INSTABILITYRDNA TRANSCRIPTIONUBIQUITIN LIGASESYNDROME GENEPHD FINGERSHUMAN ELG1LIFE-SPAN

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