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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation

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Title
IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation
Author
Ramazzotti, GiuliaBilli, Anna MariaManzoli, LuciaMazzetti, CristinaRuggeri, AlessandraErneux, ChristopheKim, SeyunSuh, Pann-GhillCocco, LucioFaenza, Irene
Keywords
myogenic differentiation;  phospholipase C-β1;  IPMK;  β-catenin;  inositol phosphates
Issue Date
201608
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v.7, no.51, pp.84118 - 84127
Abstract
In previous studies, we have reported that phospholipase C (PLC)-β1 plays a crucial role in myogenic differentiation and we determined the importance of its catalytic activity for the initiation of this process. Here we define the effectors that take part to its signaling pathway. We show that the Inositol Polyphosphate Multikinase (IPMK) is able to promote myogenic differentiation since its overexpression determines the up-regulation of several myogenic markers. Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region targeted by PLC-β1 and that IPMKinduced promoter activation relies upon c-jun binding to the promoter, as we have shown previously for PLC-β1. Furthermore, our data shows that IPMK overexpression causes an increase in β-catenin translocation and accumulation to the nuclei of differentiating myoblasts resulting in higher MyoD activation. Finally, we describe that PLC-β1 overexpression determines too an increase in β-catenin translocation and that PLC-β1, IPMK and β-catenin are mediators of the same signaling pathway since their overexpression results in cyclin D3 and myosin heavy chain (MYH) induction.
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DOI
http://dx.doi.org/10.18632/oncotarget.11527
ISSN
1949-2553
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SLS_Journal Papers
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