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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization

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Title
Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization
Author
Kwon, OhmanKwak, DongohHa, Sang HoonJeon, HyeonaPark, MangeunChang, YeonhoSuh, Pann-GhillRyu S.H.
Keywords
Mammalian target of rapamycin complex 1 (mTORC1); Rag GTPases; Nudix-type motif 2 (NUDT2); Lysosomal localization; Cancer cell proliferation
Issue Date
201704
Publisher
ELSEVIER SCIENCE INC
Citation
CELLULAR SIGNALLING, v.32, no., pp.24 - 35
Abstract
Lysosomal localization of mammalian target of rapamycin complex 1 (mTORC1) is a critical step for activation of the molecule. Rag GTPases are essential for this translocation. Here, we demonstrate that Nudix-type motif 2 (NUDT2) is a novel positive regulator of mTORC1 activation. Activation of mTORC1 is impaired in NUDT2-silenced cells. Mechanistically, NUDT2 binds to Rag GTPase and controls mTORC1 translocation to the lysosomal membrane. Furthermore, NUDT2-dependent mTORC1 regulation is critical for proliferation of breast cancer cells, as NUDT2-silenced cells arrest in G0/G1 phases. Taken together, these results show that NUDT2 is a novel complex formation enhancing factor regulating mTORC1-Rag GTPase signaling that is crucial for cell growth control.
URI
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DOI
http://dx.doi.org/10.1016/j.cellsig.2017.01.015
ISSN
0898-6568
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