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김학선

Kim, Hak Sun
Internet of Things System Lab.
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Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells

Author(s)
Kim, Hak SunPark, Won SangBaek, Jong-InLee, Bo-SubYoo, Dae SungPark, Si Jun
Issued Date
2015-02
DOI
10.3892/ijmm.2014.2030
URI
https://scholarworks.unist.ac.kr/handle/201301/21535
Fulltext
https://www.spandidos-publications.com/10.3892/ijmm.2014.2030
Citation
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.35, no.2, pp.383 - 390
Abstract
Accumulating evidence has indicated that the light source emitted from light-emitting diode (LED) has a potential anti-aging effect on human skin. Studies using single and interval LED irradiation have documented such effects; however, to the best of our knowledge, the anti-aging effects of continuous LED irradiation have not yet been investigated. In the present study, we demonstrated that continuous irradiation with a 633 +/- 3-nm LED exerted anti-aging effects in both in vitro and ex vivo experiments. More specifically, irradiation with a 633-nm LED for 2 days increased the synthesis of type 1 procollagen and decreased the expression of matrix metalloproteinase (MMP)1 and MMP2 in skin fibroblasts. In addition, irradiation with a 633-nm LED decreased the expression levels of inflammatory genes, such has cyclooxygenase-2 (COX-2), and interleukin-1-alpha (IL-1 alpha) in keratinocytes. Furthermore, a 14-day LED irradiation moderately increased keratinocyte proliferation. Using human skin explants, we confirmed the safety of this 633-nm LED irradiation, which resulted in unaltered morphology and allergy-free potential in human tissue. Overall, these data provide insight into the anti-aging effects of continuous LED irradiation on human skin.
Publisher
SPANDIDOS PUBL LTD
ISSN
1107-3756
Keyword (Author)
light-emitting diode633 nm wavelengthskinanti-agingirradiation
Keyword
INTENSE PULSED-LIGHTHUMAN KERATINOCYTESHUMAN FIBROBLASTSMOUSE SKINEXPRESSIONCOLLAGENMETABOLISMEXPOSURERELEASEEXTRACT

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