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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase Cγ in Toll-like receptor-mediated inflammation and innate immunity

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Title
Phospholipase Cγ in Toll-like receptor-mediated inflammation and innate immunity
Author
Bae, Yoe-SikLee, Ha YoungJung, Young SuLee, MingyuSuh, Pann-Ghill
Issue Date
201701
Publisher
ELSEVIER SCI LTD
Citation
ADVANCES IN BIOLOGICAL REGULATION, v.63, no., pp.92 - 97
Abstract
Among the phospholipase C (PLC) isoforms, PLCγ not only has unique structural characteristics in terms of harboring SH2 and SH3 domains but also mediates growth factor-induced signaling pathways. PLCγ isoforms are expressed in several innate immune cell types, including macrophages, natural killer cells, mast cells, and neutrophils. Stimulation of Fc receptor or integrin in innate immune cells induces PLCγ activation, which leads to phosphoinositide hydrolysis and calcium increase. The products of PLCγ activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. PLCγ also regulates the inflammatory response by affecting Toll-like receptor-mediated signaling. Here, we briefly review the current understanding of the functional role of PLCγ in inflammation and innate immunity in some innate immune cell types.
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DOI
http://dx.doi.org/10.1016/j.jbior.2016.09.006
ISSN
2212-4934
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