There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 940 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 930 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 146 | - |
dc.contributor.author | Fu, Yu V. | - |
dc.contributor.author | Yardimci, Hasan | - |
dc.contributor.author | Long, David T. | - |
dc.contributor.author | The Vinh Ho | - |
dc.contributor.author | Guainazzi, Angelo | - |
dc.contributor.author | Bermudez, Vladimir P. | - |
dc.contributor.author | Hurwitz, Jerard | - |
dc.contributor.author | van Oijen, Antoine | - |
dc.contributor.author | Schaerer, Orlando D. | - |
dc.contributor.author | Walter, Johannes C. | - |
dc.date.accessioned | 2023-12-22T05:46:05Z | - |
dc.date.available | 2023-12-22T05:46:05Z | - |
dc.date.created | 2017-01-26 | - |
dc.date.issued | 2011-09 | - |
dc.description.abstract | The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism. In some models, CMG encircles and translocates along one strand of DNA while excluding the other strand. In others, CMG encircles and translocates along duplex DNA. To distinguish between these models, replisomes were confronted with strand-specific DNA roadblocks in Xenopus egg extracts. An ssDNA translocase should stall at an obstruction on the translocation strand but not the excluded strand, whereas a dsDNA translocase should stall at obstructions on either strand. We found that replisomes bypass large roadblocks on the lagging strand template much more readily than on the leading strand template. Our results indicate that CMG is a 3' to 5' ssDNA translocase, consistent with unwinding via "steric exclusion." Given that MCM2-7 encircles dsDNA in G1, the data imply that formation of CMG in S phase involves remodeling of MCM2-7 from a dsDNA to a ssDNA binding mode0 | - |
dc.identifier.bibliographicCitation | CELL, v.146, no.6, pp.930 - 940 | - |
dc.identifier.doi | 10.1016/j.cell.2011.07.045 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-80052942659 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/21256 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867411008890 | - |
dc.identifier.wosid | 000295258100015 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INTERSTRAND CROSS-LINK | - |
dc.subject.keywordPlus | MINICHROMOSOME MAINTENANCE PROTEIN | - |
dc.subject.keywordPlus | MCM2-7 HELICASE | - |
dc.subject.keywordPlus | HEXAMERIC HELICASE | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CDC45 | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | ORIGIN | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.