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Lee, Semin
Computational Biology Lab
Research Interests
  • Cancer genomics & single-cell genomics

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Integrated genomic and molecular characterization of cervical cancer

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dc.contributor.authorThe Cancer Genome Atlas Research Networkko
dc.contributor.authorLee, Seminko
dc.date.available2017-01-31T05:37:43Z-
dc.date.created2017-01-31ko
dc.date.issued201703ko
dc.identifier.citationNATURE, v.543, no., pp.378 - 384ko
dc.identifier.issn0028-0836ko
dc.identifier.urihttp://scholarworks.unist.ac.kr/handle/201301/21228-
dc.identifier.urihttp://www.nature.com/nature/journal/vaap/ncurrent/full/nature21386.htmlko
dc.description.abstractCervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, the largest comprehensive genomic study of cervical cancer to date. We observed striking APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A, and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered novel amplifications in immune targets CD274/PD-L1 and PDCD1LG2/PD-L2, and the BCAR4 lncRNA that has been associated with response to lapatinib. HPV integration was observed in all HPV18-related cases and 76% of HPV16-related cases, and was associated with structural aberrations and increased target gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumors with high frequencies of KRAS, ARID1A, and PTEN mutations. Integrative clustering of 178 samples identified Keratin-low Squamous, Keratin-high Squamous, and Adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.ko
dc.description.statementofresponsibilityclose-
dc.languageENGko
dc.publisherNATURE PUBLISHING GROUPko
dc.titleIntegrated genomic and molecular characterization of cervical cancerko
dc.typeARTICLEko
dc.identifier.pid2988null
dc.identifier.rimsid27790ko
dc.identifier.wosid000396337400042ko
dc.type.rimsAko
dc.identifier.doihttp://dx.doi.org/10.1038/nature21386ko
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