BROWSE

Related Researcher

Author

Lee, Semin
Computational Biology Lab
Research Interests
  • Cancer genomics & single-cell genomics

ITEM VIEW & DOWNLOAD

Integrated genomic characterization of oesophageal carcinoma

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Integrated genomic characterization of oesophageal carcinoma
Author
Lee, Semin
Issue Date
201701
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE, v.541, no., pp.169 - 175
Abstract
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.
URI
Go to Link
DOI
http://dx.doi.org/10.1038/nature20805
ISSN
0028-0836
Appears in Collections:
SLS_Journal Papers
Files in This Item:
nature20805.pdfDownload

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU