There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 519 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 503 | - |
dc.citation.title | NANO RESEARCH | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Kim, Seongchan | - |
dc.contributor.author | Choi, Yuri | - |
dc.contributor.author | Park, Ginam | - |
dc.contributor.author | Won, Cheolhee | - |
dc.contributor.author | Park, Young-Joon | - |
dc.contributor.author | Lee, Younghoon | - |
dc.contributor.author | Kim, Byeong-Su | - |
dc.contributor.author | Min, Dal-Hee | - |
dc.date.accessioned | 2023-12-21T22:41:19Z | - |
dc.date.available | 2023-12-21T22:41:19Z | - |
dc.date.created | 2016-11-28 | - |
dc.date.issued | 2017-02 | - |
dc.description.abstract | Small interfering RNA (siRNA) is an attractive therapeutic candidate for sequencespecific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot (CD), and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles (NPs) enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein (GFP) expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy. | - |
dc.identifier.bibliographicCitation | NANO RESEARCH, v.10, no.2, pp.503 - 519 | - |
dc.identifier.doi | 10.1007/s12274-016-1309-1 | - |
dc.identifier.issn | 1998-0124 | - |
dc.identifier.scopusid | 2-s2.0-84994448306 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20928 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12274-016-1309-1 | - |
dc.identifier.wosid | 000394322300013 | - |
dc.language | 영어 | - |
dc.publisher | TSINGHUA UNIV PRESS | - |
dc.title | Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science; Physics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | bioimaging | - |
dc.subject.keywordAuthor | carbon dot | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | RNA interference | - |
dc.subject.keywordAuthor | targeted cancer therapy | - |
dc.subject.keywordPlus | LOW-MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | HIGH QUANTUM YIELD | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | FUNCTIONAL DELIVERY | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | NANODOTS SYNTHESIS | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.