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김병수

Kim, Byeong-Su
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dc.citation.endPage 3639 -
dc.citation.number 11 -
dc.citation.startPage 3632 -
dc.citation.title BIOMACROMOLECULES -
dc.citation.volume 17 -
dc.contributor.author Song, Suhee -
dc.contributor.author Lee, Joonhee -
dc.contributor.author Kweon, Songa -
dc.contributor.author Song, Jaeeun -
dc.contributor.author Kim, Kyuseok -
dc.contributor.author Kim, Byeong-Su -
dc.date.accessioned 2023-12-21T23:07:39Z -
dc.date.available 2023-12-21T23:07:39Z -
dc.date.created 2016-12-02 -
dc.date.issued 2016-11 -
dc.description.abstract Functional hyperbranched polyglycerols (PGs) have recently garnered considerable interest due to their potential in biomedical applications. Here, we present a one-pot synthesis of hyperbranched PGs possessing amine functionality using a novel amino glycidyl ether monomer. A Boc-protected butanolamine glycidyl ether (BBAG) monomer was designed and polymerized with glycidol (G) through anionic ring-opening multibranching polymerization to yield a series of hyperbranched P(G-co-BBAG) with controlled molecular weights (4800-16700 g/mol) and relatively low molecular weight distributions (1.2-1.6). The copolymerization and subsequent deprotection chemistry allow the incorporation of an adjustable fraction of primary amine moieties (typically, 5-20% monomer ratio) within the hyperbranched PG backbones, thus providing potentials for varying charge densities and functionality in PGs. The copolymerization kinetics of G and BBAG was also evaluated using a quantitative in situ 13C NMR spectroscopic analysis, which revealed gradient copolymerization between the comonomers. The free amine groups within the deprotected P(G-co-BAG) copolymer were further utilized for a facile conjugation chemistry with a model molecule in a quantitative manner. Furthermore, the superior biocompatibility of the prepared P(G-co-BAG) polymers was demonstrated via cell viability assays, outperforming many existing polyamines possessing relatively high cytotoxicity. Taken together, the biocompatibility with facile conjugation chemistry of free amine groups sheathed within the framework of hyperbranched PGs holds the prospect of advancing biological and biomedical applications. -
dc.identifier.bibliographicCitation BIOMACROMOLECULES, v.17, no.11, pp.3632 - 3639 -
dc.identifier.doi 10.1021/acs.biomac.6b01136 -
dc.identifier.issn 1525-7797 -
dc.identifier.scopusid 2-s2.0-84995700040 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/20903 -
dc.identifier.url http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b01136 -
dc.identifier.wosid 000388155400019 -
dc.language 영어 -
dc.publisher AMER CHEMICAL SOC -
dc.title Hyperbranched Copolymers Based on Glycidol and Amino Glycidyl Ether: Highly Biocompatible Polyamines Sheathed in Polyglycerols -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Chemistry; Polymer Science -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus FUNCTIONALIZED DENDRITIC POLYGLYCEROL -
dc.subject.keywordPlus POLY(ETHYLENE GLYCOL) -
dc.subject.keywordPlus DRUG-DELIVERY -
dc.subject.keywordPlus POLYETHER POLYOLS -
dc.subject.keywordPlus POLYMERIZATION -
dc.subject.keywordPlus MICELLES -
dc.subject.keywordPlus MONOMER -
dc.subject.keywordPlus DERIVATIVES -
dc.subject.keywordPlus OXIDE -
dc.subject.keywordPlus BLOCK -

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