BROWSE

Related Researcher

Author

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion
Author
Lee, Yu JinShin, Kyeong JinPark, Soo-AhPark, Kyeong SuPark, SeorimHeo, KyunSeo, Young KyoNoh, Dong-YoungRyu, Sung HoSuh, Pann-Ghill
Keywords
GPR81; breast cancer; amphiregulin; angiogenesis; Akt
Issue Date
201609
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v.7, no.43, pp.70898 - 70911
Abstract
G-protein-coupled receptor 81 (GPR81) functions as a receptor for lactate and plays an important role in the regulation of anti-lipolytic effects in adipocytes. However, to data, a role for GPR81 in the tumor microenvironment has not been clearly defined. Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells. GPR81 knockdown resulted in impaired breast cancer growth and led to apoptosis both in vitro and in vivo. Furthermore, the inhibition of GPR81 signaling suppressed angiogenesis through a phosphoinositide 3-OH kinase (PI3K)/Akt-cAMP response element binding protein (CREB) pathway, which led to decreased production of the pro-angiogenic mediator amphiregulin (AREG). Overall, these findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K/Akt signaling axis in tumor microenvironment.
URI
Go to Link
DOI
http://dx.doi.org/10.18632/oncotarget.12286
ISSN
1949-2553
Appears in Collections:
SLS_Journal Papers
Files in This Item:
2-s2.0-84994291790.pdfDownload

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU