File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

강현욱

Kang, Hyun-Wook
3D Biofabrication Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

A 3D bioprinted complex structure for engineering the muscle-tendon unit

Author(s)
Merceron, Tyler KBurt, MorganSeol, Young-JoonKang, Hyun-WookLee, Sang JinYoo, James JAtala, Anthony
Issued Date
2015-06
DOI
10.1088/1758-5090/7/3/035003
URI
https://scholarworks.unist.ac.kr/handle/201301/20482
Fulltext
http://iopscience.iop.org/article/10.1088/1758-5090/7/3/035003/meta
Citation
BIOFABRICATION, v.7, no.3, pp.035003
Abstract
Three-dimensional integrated organ printing (IOP) technology seeks to fabricate tissue constructs that can mimic the structural and functional properties of native tissues. This technology is particularly useful for complex tissues such as those in the musculoskeletal system, which possess regional differences in cell types and mechanical properties. Here, we present the use of our IOP system for the processing and deposition of four different components for the fabrication of a single integrated muscle-tendon unit (MTU) construct. Thermoplastic polyurethane (PU) was co-printed with C2C12 cell-laden hydrogel-based bioink for elasticity and muscle development on one side, while poly(epsilon-caprolactone) (PCL) was co-printed with NIH/3T3 cell-laden hydrogel-based bioink for stiffness and tendon development on the other. The final construct was elastic on the PU-C2C12 muscle side (E = 0.39 ± 0.05 MPa), stiff on the PCL-NIH/3T3 tendon side (E = 46.67 ± 2.67 MPa) and intermediate in the interface region (E = 1.03 ± 0.14 MPa). These constructs exhibited >80% cell viability at 1 and 7 d after printing, as well as initial tissue development and differentiation. This study demonstrates the versatility of the IOP system to create integrated tissue constructs with region-specific biological and mechanical characteristics for MTU engineering.
Publisher
IOP PUBLISHING LTD
ISSN
1758-5082

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.