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DC Field | Value | Language |
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dc.citation.endPage | 4191 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 4183 | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 76 | - |
dc.contributor.author | Zhang, Yongliang | - |
dc.contributor.author | Fox, Jennifer T. | - |
dc.contributor.author | Park, Young-Un | - |
dc.contributor.author | Elliott, Gene | - |
dc.contributor.author | Rai, Ganesha | - |
dc.contributor.author | Cai, Mengli | - |
dc.contributor.author | Sakamuru, Srilatha | - |
dc.contributor.author | Huang, Ruili | - |
dc.contributor.author | Xia, Menghang | - |
dc.contributor.author | Lee, Kyeryoung | - |
dc.contributor.author | Jeon, Min Ho | - |
dc.contributor.author | Mathew, Bijoy P. | - |
dc.contributor.author | Park, Hee Dong | - |
dc.contributor.author | Edelmann, Winfried | - |
dc.contributor.author | Park, Chan Young | - |
dc.contributor.author | Hong, Sung You | - |
dc.contributor.author | Maloney, David | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-21T23:37:39Z | - |
dc.date.available | 2023-12-21T23:37:39Z | - |
dc.date.created | 2016-07-14 | - |
dc.date.issued | 2016-07 | - |
dc.description.abstract | Impairing the division of cancer cells with genotoxic small molecules has been a primary goal to develop chemotherapeutic agents. However, DNA mismatch repair (MMR)-deficient cancer cells, are resistant to most conventional chemotherapeutic agents. Here we have identified baicalein as a small molecule that selectively kills MutSα-deficient cancer cells. Baicalein binds preferentially to mismatched DNA and induces a DNA damage response in a mismatch repair-dependent manner. In MutSα-proficient cells, baicalein binds to MutSα to dissociate CHK2 from MutSα leading to S phase arrest and cell survival. In contrast, continued replication in the presence of baicalein in MutSα-deficient cells results in a high number of DNA double-strand breaks and ultimately leads to apoptosis. Consistently, baicalein specifically shrinks MutSα-deficient xenograft tumors and inhibits the growth of AOM-DSS-induced colon tumors in colon-specific MSH2 knockout mice. Collectively, baicalein offers the potential of an improved treatment option for patients with tumors with a DNA MMR deficiency. | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.76, no.14, pp.4183 - 4191 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-15-2974 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.scopusid | 2-s2.0-84978419126 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20473 | - |
dc.identifier.url | http://cancerres.aacrjournals.org/content/76/14/4183 | - |
dc.identifier.wosid | 000381111400016 | - |
dc.language | 영어 | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | DAMAGE RESPONSE | - |
dc.subject.keywordPlus | BAICALEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | SCUTELLARIA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.subject.keywordPlus | DEFECTS | - |
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