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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

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Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications

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Title
Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications
Author
Nam, Jung SeungKang, Myeong-GyunKang, JuhyePark, Sun-YoungLee, Shin Jung CKim, Hyun-TakSeo, Jeong KonKwon, Oh HoonLim, Mi HeeRhee, Hyun-WooKwon, Tae-Hyuk
Issue Date
201608
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.138, no.34, pp.10968 - 10977
Abstract
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (1O2) and superoxide radical (O2•–) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct involvement in photodynamic therapy (PDT) have not been revealed. Herein, we report Ir(III) complexes designed for ROS generation through a rational strategy to investigate protein modifications by ROS. The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation (≤ 1 J cm–2) because of the relatively high 1O2 quantum yield (> 0.78), even with two-photon activation. Furthermore, two types of protein modifications (protein oxidation and photo-cross-linking) involved in PDT were characterized by mass spectrometry. These modifications were generated primarily in the endoplasmic reticulum and mitochondria, producing a significant effect for cancer cell death. Consequently, we present a plausible biologically applicable PDT modality that utilizes rationally designed photoactivatable Ir(III) complexes.
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DOI
http://dx.doi.org/10.1021/jacs.6b05302
ISSN
0002-7863
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