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- Kim, Yong Hwan
- Enzyme and Protein Engineering Lab.
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Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates
- Author(s)
- Quang Anh Tuan Le, Chang, Rakwoo, Kim, Yong Hwan
- Issued Date
- 2015-08
- Citation
- CHEMICAL COMMUNICATIONS, v.51, no.77, pp.14536 - 14539
- Abstract
- A rational design of paraoxonase 1 based on molecular docking discovered H115W/T332S and I74F/H115W/T332S mutants exhibited a 40-fold increase in catalytic efficiency (k(cat)/K-m) toward the hydrolysis of two toxic and popular organophosphates (diethyl-paraoxon and dimethyl-paraoxon). Moreover, the conversion of the paraoxons (741.3-825.6 mg L-1) by the evolved mutants was 42-60-fold faster than that by the wild type
- Publisher
- ROYAL SOC CHEMISTRY
- ISSN
- 1359-7345
- Keyword
- EXPRESSION, PROTECTS
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