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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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A lab-on-a-disc with reversible and thermally stable diaphragm valves

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Title
A lab-on-a-disc with reversible and thermally stable diaphragm valves
Author
Kim, Tae-HyeongSunkara, VijayaPark, JuheeKim, Chi-JuWoo, Hyun-KyungCho, Yoon-Kyoung
Issue Date
201610
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.16, no.19, pp.3741 - 3749
Abstract
Lab-on-a-disc is a unique microfluidic platform that utilizes centrifugal force to pump liquids. This offers many benefits for point-of-care devices because it eliminates the need for connections to multiple pumps and complex tubing connections. Broad applications including clinical chemistry, immunoassay, cell analysis, as well as nucleic acid tests, could be demonstrated on a spinning disc. To enable the performance of assays in a fully integrated and automated manner, the robust actuation of integrated valves is a prerequisite. However, conventional passive type of valves incur a critical drawback in that their operation is dependent on the rotational frequency, which is easily influenced by the channel geometry and chemistry, in addition to the physical properties of the liquids to be transferred. Even though a few active type valving techniques permit the individual actuation of valves, independent of the rotational frequency, complex procedures for the fabrication as well as actuation mechanisms have prevented their broader acceptance in general applications. Here, we report on lab-on-a-disc incorporating individually addressable diaphragm valves (ID valves), which enable the reversible and thermally stable actuation of multiple valves with unprecedented ease and robustness. An ID valve is configured from an elastic epoxy diaphragm embedded on a 3D printed push-and-twist valve, which can be easily actuated by a simple automatic driver unit. As a proof of concept experiment, an enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) were performed on a disc in a fully automated manner to demonstrate the robust, reversible, leak-free, and thermally stable actuation of the valves.
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DOI
http://dx.doi.org/10.1039/C6LC00629A
ISSN
1473-0197
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