BROWSE

Related Researcher

Author

Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

ITEM VIEW & DOWNLOAD

Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells
Author
Hwang, Hyun-dooShin, ChangsikPark, JuheeKang, EnochChoi, Bang-seoHan, Jae-ADo, YoonkyungRyu, Seong-hoCho, Yoon-Kyoung
Issue Date
201607
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.6, no., pp.30207 -
Abstract
Breast cancer remains as a challenging disease with high mortality in women. Increasing evidence points the importance of understanding a crosstalk between breast cancers and immune cells, but little is known about the effect of breast cancer-derived factors on the migratory properties of dendritic cells (DCs) and their consequent capability in inducing T cell immune responses. Utilizing a unique 3D microfluidic device, we here showed that breast cancers (MCF-7, MDA-MB-231, MDA-MB-436 and SK-BR-3)-derived soluble factors increase the migration of DCs toward CCL19. The enhanced migration of DCs was mainly mediated via the highly activated JNK/c-Jun signaling pathway, increasing their directional persistence, while the velocity of DCs was not influenced, particularly when they were co-cultured with triple negative breast cancer cells (TNBCs or MDA-MB-231 and MDA-MB-436). The DCs up-regulated inflammatory cytokines IL-1β and IL-6 and induced T cells more proliferative and resistant against activation-induced cell death (AICD), which secret high levels of inflammatory cytokines IL-1β, IL-6 and IFN-γ. This study demonstrated new possible evasion strategy of TNBCs utilizing their soluble factors that exploit the directionality of DCs toward chemokine responses, leading to the building of inflammatory milieu which may support their own growth.
URI
Go to Link
DOI
http://dx.doi.org/10.1038/srep30207
ISSN
2045-2322
Appears in Collections:
SLS_Journal Papers
Files in This Item:
2-s2.0-84979582113.pdfDownload

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU