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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 852 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 839 | - |
dc.citation.title | CANCER CELL | - |
dc.citation.volume | 23 | - |
dc.contributor.author | Kim, Eunhee | - |
dc.contributor.author | Kim, Misuk | - |
dc.contributor.author | Woo, Dong-Hun | - |
dc.contributor.author | Shin, Yongjae | - |
dc.contributor.author | Shin, Jihye | - |
dc.contributor.author | Chang, Nakho | - |
dc.contributor.author | Oh, Young Taek | - |
dc.contributor.author | Kim, Hong | - |
dc.contributor.author | Rheey, Jingeun | - |
dc.contributor.author | Nakano, Ichiro | - |
dc.contributor.author | Lee, Cheolju | - |
dc.contributor.author | Joo, Kyeung Min | - |
dc.contributor.author | Rich, Jeremy N. | - |
dc.contributor.author | Nam, Do-Hyun | - |
dc.contributor.author | Lee, Jeongwu | - |
dc.date.accessioned | 2023-12-22T03:44:34Z | - |
dc.date.available | 2023-12-22T03:44:34Z | - |
dc.date.created | 2016-08-02 | - |
dc.date.issued | 2013-06 | - |
dc.description.abstract | Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homo log 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. The EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it requires a specific phosphorylation of EZH2. Inhibition of EZH2 reverses the silencing of Polycomb target genes and diminishes STAT3 activity, suggesting therapeutic strategies | - |
dc.identifier.bibliographicCitation | CANCER CELL, v.23, no.6, pp.839 - 852 | - |
dc.identifier.doi | 10.1016/j.ccr.2013.04.008 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.scopusid | 2-s2.0-84879000598 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20170 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1535610813001773 | - |
dc.identifier.wosid | 000320350900015 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TUMOR-INITIATING CELLS | - |
dc.subject.keywordPlus | GROUP PROTEIN EZH2 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | BRAIN-TUMORS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | HISTONE METHYLTRANSFERASE | - |
dc.subject.keywordPlus | DEVELOPMENTAL REGULATORS | - |
dc.subject.keywordPlus | MEDIATED REPRESSION | - |
dc.subject.keywordPlus | POLYCOMB COMPLEX | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
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