There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 358 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 345 | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 59 | - |
dc.contributor.author | Kang, Hee-Bum | - |
dc.contributor.author | Fan, Jun | - |
dc.contributor.author | Lin, Ruiting | - |
dc.contributor.author | Elf, Shannon | - |
dc.contributor.author | Ji, Quanjiang | - |
dc.contributor.author | Zhao, Liang | - |
dc.contributor.author | Jin, Lingtao | - |
dc.contributor.author | Seo, Jae Ho | - |
dc.contributor.author | Shan, Changliang | - |
dc.contributor.author | Arbiser, Jack L. | - |
dc.contributor.author | Cohen, Cynthia | - |
dc.contributor.author | Brat, Daniel | - |
dc.contributor.author | Miziorko, Henry M. | - |
dc.contributor.author | Kim, Eunhee | - |
dc.contributor.author | Abdel-Wahab, Omar | - |
dc.contributor.author | Merghoub, Taha | - |
dc.contributor.author | Froehling, Stefan | - |
dc.contributor.author | Scholl, Claudia | - |
dc.contributor.author | Tamayo, Pablo | - |
dc.contributor.author | Barbie, David A. | - |
dc.contributor.author | Zhou, Lu | - |
dc.contributor.author | Pollack, Brian P. | - |
dc.contributor.author | Fisher, Kevin | - |
dc.contributor.author | Kudchadkar, Ragini R. | - |
dc.contributor.author | Lawson, David H. | - |
dc.contributor.author | Sica, Gabriel | - |
dc.contributor.author | Rossi, Michael | - |
dc.contributor.author | Lonial, Sagar | - |
dc.contributor.author | Khoury, Hanna J. | - |
dc.contributor.author | Khuri, Fadlo R. | - |
dc.contributor.author | Lee, Benjamin H. | - |
dc.contributor.author | Boggon, Titus J. | - |
dc.contributor.author | He, Chuan | - |
dc.contributor.author | Kang, Sumin | - |
dc.contributor.author | Chen, Jing | - |
dc.date.accessioned | 2023-12-22T00:48:41Z | - |
dc.date.available | 2023-12-22T00:48:41Z | - |
dc.date.created | 2016-08-02 | - |
dc.date.issued | 2015-08 | - |
dc.description.abstract | Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic alterations are required for tumor development. Here we demonstrate a "synthetic lethal'' interaction between oncogenic BRAF V600E and a ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL). HMGCL expression is upregulated in BRAF V600E-expressing human primary melanoma and hairy cell leukemia cells. Suppression of HMGCL specifically attenuates proliferation and tumor growth potential of human melanoma cells expressing BRAF V600E. Mechanistically, active BRAF upregulates HMGCL through an octamer transcription factor Oct-1, leading to increased intracellular levels of HMGCL product, acetoacetate, which selectively enhances binding of BRAF V600E but not BRAF wild-type to MEK1 in V600E-positive cancer cells to promote activation of MEK-ERK signaling. These findings reveal a mutation-specific mechanism by which oncogenic BRAF V600E "rewires'' metabolic and cell signaling networks and signals through the Oct-1-HMGCL-acetoacetate axis to selectively promote BRAF V600E-dependent tumor development. | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.59, no.3, pp.345 - 358 | - |
dc.identifier.doi | 10.1016/j.molcel.2015.05.037 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.scopusid | 2-s2.0-84938588282 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20162 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1097276515004384 | - |
dc.identifier.wosid | 000362457600003 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | HAIRY-CELL LEUKEMIA | - |
dc.subject.keywordPlus | KETONE-BODY METABOLISM | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | LYSINE ACETYLATION | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DEHYDROGENASE | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | KINASE | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.