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Cho, Hyungjoon
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UTE-Delta R-2-Delta R-2* combined MR whole-brain angiogram using dual-contrast superparamagnetic iron oxide nanoparticles

Author(s)
Jung H.S.Jin S.H.Cho, J.H.Han S.H.Lee D.K.Cho, Hyungjoon
Issued Date
2016-06
DOI
10.1002/nbm.3514
URI
https://scholarworks.unist.ac.kr/handle/201301/19981
Fulltext
http://onlinelibrary.wiley.com/doi/10.1002/nbm.3514/abstract
Citation
NMR IN BIOMEDICINE, v.29, no.6, pp.690 - 701
Abstract
The ability to visualize whole-brain vasculature is important for quantitative in vivo investigation of vascular malfunctions in cerebral small vessel diseases, including cancer, stroke and neurodegeneration. Transverse relaxation-based Delta R-2 and Delta R-2* MR angiography (MRA) provides improved vessel-tissue contrast in animal deep brain with the aid of intravascular contrast agents; however, it is susceptible to orientation dependence, air-tissue interface artifacts and vessel size overestimation. Dual-mode MRA acquisition with superparamagnetic iron oxide nanoparticles (SPION) provides a unique opportunity to systematically compare and synergistically combine both longitudinal (R-1) and transverse (Delta R-2 and Delta R-2*) relaxation-based MRA. Through Monte Carlo (MC) simulation and MRA experiments in normal and tumor-bearing animals with intravascular SPION, we show that ultrashort TE (UTE) MRA acquires well-defined vascularization on the brain surface, minimizing air-tissue artifacts, and combined Delta R-2 and Delta R-2* MRA simultaneously improves the sensitivity to intracortical penetrating vessels and reduces vessel size overestimation. Consequently, UTE-Delta R-2-Delta R-2* combined MRA complements the shortcomings of individual angiograms and provides a strategy to synergistically merge longitudinal and transverse relaxation effects to generate more robust in vivo whole-brain micro-MRA.
Publisher
WILEY-BLACKWELL
ISSN
0952-3480
Keyword (Author)
micro-MR angiographydual-contrast SPIONultrashort echo
Keyword
PERMEABILITYMAGNETIC-RESONANCE ANGIOGRAPHYCEREBRAL BLOOD-VOLUMESUSCEPTIBILITY ARTIFACTSTUMOR ANGIOGENESISMICRO-MRIVISUALIZATIONSIZEMICROVASCULATUREQUANTIFICATION

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