File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

박지영

Park, Jiyoung
Molecular Metabolism Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Hyperglycemic memory in metabolism and cancer

Author(s)
Lee, ChanghuAn, DohyeonPark, Jiyoung
Issued Date
2016-05
DOI
10.1515/hmbci-2016-0022
URI
https://scholarworks.unist.ac.kr/handle/201301/19474
Fulltext
http://www.degruyter.com/view/j/hmbci.2016.26.issue-2/hmbci-2016-0022/hmbci-2016-0022.xml
Citation
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, v.26, no.2, pp.77 - 85
Abstract
Hyperglycemia is a hallmark of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Recent evidence strongly suggests that prolonged exposure to hyperglycemia can epigenetically modify gene expression profiles in human cells and that this effect is sustained even after hyperglycemic control is therapeutically achieved; this phenomenon is called hyperglycemic memory. This metabolic memory effect contributes substantially to the pathology of various diabetic complications, such as diabetic retinopathy, hypertension, and diabetic nephropathy. Due to the metabolic memory in cells, diabetic patients suffer from various complications, even after hyperglycemia is controlled. With regard to this strong association between diabetes and cancer risk, cancer cells have emerged as key target cells of hyperglycemic memory in diabetic cancer patients. In this review, we will discuss the recent understandings of the molecular mechanisms underlying hyperglycemic memory in metabolism and cancer.
Publisher
Walter de Gruyter GmbH & Co.
ISSN
1868-1883

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.