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박정훈

Park, Jung-Hoon
Bio-Optics Lab.
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dc.citation.endPage 9241 -
dc.citation.number 30 -
dc.citation.startPage 9236 -
dc.citation.title PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA -
dc.citation.volume 112 -
dc.contributor.author Park, Jung-Hoon -
dc.contributor.author Sun, Wei -
dc.contributor.author Cui, Meng -
dc.date.accessioned 2023-12-22T01:07:17Z -
dc.date.available 2023-12-22T01:07:17Z -
dc.date.created 2016-06-07 -
dc.date.issued 2015-07 -
dc.description.abstract Multiphoton microscopy is the current method of choice for in vivo deep-tissue imaging. The long laser wavelength suffers less scattering, and the 3D-confined excitation permits the use of scattered signal light. However, the imaging depth is still limited because of the complex refractive index distribution of biological tissue, which scrambles the incident light and destroys the optical focus needed for high resolution imaging. Here, we demonstrate a wavefront-shaping scheme that allows clear imaging through extremely turbid biological tissue, such as the skull, over an extended corrected field of view (FOV). The complex wavefront correction is obtained and directly conjugated to the turbid layer in a noninvasive manner. Using this technique, we demonstrate in vivo submicron-resolution imaging of neural dendrites and microglia dynamics through the intact skulls of adult mice. This is the first observation, to our knowledge, of dynamic morphological changes of microglia through the intact skull, allowing truly noninvasive studies of microglial immune activities free from external perturbations. -
dc.identifier.bibliographicCitation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.112, no.30, pp.9236 - 9241 -
dc.identifier.doi 10.1073/pnas.1505939112 -
dc.identifier.issn 0027-8424 -
dc.identifier.scopusid 2-s2.0-84938099475 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/19465 -
dc.identifier.url http://www.pnas.org/content/112/30/9236 -
dc.identifier.wosid 000358656500045 -
dc.language 영어 -
dc.publisher NATL ACAD SCIENCES -
dc.title High-resolution in vivo imaging of mouse brain through the intact skull -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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