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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C

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Title
Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C
Author
Poli, AlessandroBilli, Anna MariaMongiorgi, SaraRatti, StefanoMcCubrey, James A.Suh, Pann-GhillCocco, LucioRamazzotti, Giulia
Keywords
RISK MYELODYSPLASTIC SYNDROMES; CELL-CYCLE PROGRESSION; ACUTE MYELOID-LEUKEMIA; GROWTH-FACTOR-I; MURINE ERYTHROLEUKEMIA-CELLS; SWISS 3T3-CELLS; MESSENGER-RNA; MYOGENIC DIFFERENTIATION; ERYTHROID-DIFFERENTIATION; 4-PHOSPHATE 5-KINASE
Issue Date
201608
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR PHYSIOLOGY, v.231, no.8, pp.1645 - 1655
Abstract
Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which modulate many cellular functions including cell proliferation, cell differentiation, apoptosis, and membrane trafficking. An array of kinases, phosphatases, and lipases acts on PI creating an important number of second messengers involved in different cellular processes. Although, commonly, PI signaling was described to take place at the plasma membrane, many evidences indicated the existence of a PI cycle residing in the nuclear compartment of eukaryotic cells. The discovery of this mechanism shed new light on many nuclear functions, such as gene transcription, DNA modifications, and RNA expression. As these two PI cycles take place independently of one another, understanding how nuclear lipid signaling functions and modulates nuclear output is fundamental in the study of many cellular processes.
URI
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DOI
http://dx.doi.org/10.1002/jcp.25273
ISSN
0021-9541
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