BROWSE

Related Researcher

Author

Lee-Kwon, Whaseon
School of Life Science
Research Interests
  • Calcium signalling in cancer cell

ITEM VIEW & DOWNLOAD

LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
Author
Lee, Hwan HeeSanada, SatoruAn, Seung MinYe, Byeong JinLee, Jun HoSeo, Young KyoLee, ChangwookLee-Kwon, WhaseonKüper, ChristophNeuhofer, WolfgangChoi, Soo YounKwon, H. Moo
Keywords
TRANSCRIPTION FACTOR NFAT5; INFLAMMATORY ARTHRITIS; GENE; PROTEIN; MACROPHAGES; P300; HYPERTONICITY; ACTIVATION; PATHWAYS; IMMUNITY
Issue Date
201604
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.6, no., pp.24921 -
Abstract
NFκB is a central mediator of inflammation. Present inhibitors of NFκB are mostly based on inhibition of essential machinery such as proteasome and protein kinases, or activation of nuclear receptors; as such, they are of limited therapeutic use due to severe toxicity. Here we report an LPS-induced NFκB enhanceosome in which TonEBP is required for the recruitment of p300. Increased expression of TonEBP enhances the NFκB activity and reduced TonEBP expression lowers it. Recombinant TonEBP molecules incapable of recruiting p300 do not stimulate NFκB. Myeloid-specific deletion of TonEBP results in milder inflammation and sepsis. We discover that a natural small molecule cerulenin specifically disrupts the enhanceosome without affecting the activation of NFκB itself. Cerulenin suppresses the pro-inflammatory activation of macrophages and sepsis without detectable toxicity. Thus, the NFκB enhanceosome offers a promising target for useful anti-inflammatory agents.
URI
Go to Link
DOI
http://dx.doi.org/10.1038/srep24921
ISSN
2045-2322
Appears in Collections:
SLS_Journal Papers
Files in This Item:
2-s2.0-84964838156.pdfDownload

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU