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Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia

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Title
Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein (TonEBP) in microglia
Author
Jeong, Ga RamIm, Sun-KyoungBae, Yun-HeePark, Eun SuJin, Byung KwanKwon, H. MooLee, Beom JoonBu, YoungminHur, Eun-MiLee, Byoung Dae
Keywords
LPS; Microglia; Neuroinflammation; TonEBP
Issue Date
201606
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF NEUROIMMUNOLOGY, v.295, no., pp.21 - 29
Abstract
Tonicity-responsive enhancer (TonE) binding protein (TonEBP) is known as an osmosensitive transcription factor that regulates cellular homeostasis during states of hypo- and hypertonic stress. In addition to its role in osmoadaptation, growing lines of evidence suggest that TonEBP might have tonicity-independent functions. In particular, a number of studies suggest that inflammatory stimuli induce the expression and activation of TonEBP in peripheral immune cells. However, whether TonEBP is expressed in microglia, resident immune cells of the central nervous system, is unknown. Here we show that inflammatory signals induce the expression of TonEBP in microglia both in vitro and in vitro. In cultured primary microglia, treatment with lipopolysaccharide (LPS), interferon-γ, and interleukin 4 increased the expression of TonEBP. Moreover, we found that stereotaxic injection of LPS into the substantia nigra region of rat brain increased TonEBP expression in OX-42-positive cells. Furthermore, expression of TonEBP was induced in OX-42-positive cells in a rat model of transient middle cerebral artery occlusion. Together these results show that the expression of TonEBP is regulated by inflammatory signals in mammalian brain, suggesting that TonEBP might play a part during neuroinflammation.
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DOI
http://dx.doi.org/10.1016/j.jneuroim.2016.04.009
ISSN
0165-5728
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