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- Ryu, Ja-Hyoung
- Supramolecular Nanomaterials Lab.
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The HA-incorporated nanostructure of a peptide-drug amphiphile for targeted anticancer drug delivery
- Author(s)
- Choi, Huyeon, Jeena, M. T., Palanikumar, L., Jeong, Yoojeong, Park, Sooham, Lee, Eunji, Ryu, Ja-Hyoung
- Issued Date
- 2016-04
- Citation
- CHEMICAL COMMUNICATIONS, v.52, no.32, pp.5637 - 5640
- Abstract
- A simple peptide based prodrug of camptothecin (CPT) has been synthesised in which the CPT is conjugated to a tripeptide (KCK) via a disulfide linkage (KCK-CPT) and self-assembled into well-defined nanostructures in water depending on the concentration. The hyaluronic acid (HA) complex of KCK-CPT exhibited target specific toxicity with excellent antitumour efficiency.
- Publisher
- ROYAL SOC CHEMISTRY
- ISSN
- 1359-7345
- Keyword
- HYALURONIC-ACID, CANCER, NANOCARRIERS, NANOTUBES, RELEASE, CATABOLISM
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