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- Lee, Semin
- Computational Biology Lab.
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Ulla: a program for calculating environment-specific amino acid substitution tables
- Author(s)
- Lee, Semin, Blundell, Tom L.
- Issued Date
- 2009-08
- Citation
- BIOINFORMATICS, v.25, no.15, pp.1976 - 1977
- Abstract
- Amino acid residues are under various kinds of local environmental restraints, which influence substitution patterns. Ulla,(1) a program for calculating environment-specific substitution tables, reads protein sequence alignments and local environment annotations. The program produces a substitution table for every possible combination of environment features. Sparse data is handled using an entropy-based smoothing procedure to estimate robust substitution probabilities
- Publisher
- OXFORD UNIV PRESS
- ISSN
- 1367-4803
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