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dc.citation.endPage | 550 | - |
dc.citation.number | 7511 | - |
dc.citation.startPage | 543 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 511 | - |
dc.contributor.author | Collisson, Eric A. | - |
dc.contributor.author | Campbell, Joshua D. | - |
dc.contributor.author | Brooks, Angela N. | - |
dc.contributor.author | Berger, Alice H. | - |
dc.contributor.author | Lee, William | - |
dc.contributor.author | Chmielecki, Juliann | - |
dc.contributor.author | Beer, David G. | - |
dc.contributor.author | Cope, Leslie | - |
dc.contributor.author | Creighton, Chad J. | - |
dc.contributor.author | Danilova, Ludmila | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Hammerman, Peter S. | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Hernandez, Bryan | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Heymach, John V. | - |
dc.contributor.author | Jurisica, Igor | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Kwiatkowski, David | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Robertson, Gordon | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Tsao, Ming-Sound | - |
dc.contributor.author | Travis, William D. | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Wigle, Dennis A. | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Rosenberg, Mara | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Radenbaugh, Amie | - |
dc.contributor.author | Ma, Singer | - |
dc.contributor.author | Stuart, Joshua M. | - |
dc.contributor.author | Byers, Lauren Averett | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Govindan, Ramaswamy | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Stewart, Chip | - |
dc.contributor.author | Lichtenstein, Lee | - |
dc.contributor.author | Lander, Eric S. | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Getz | - |
dc.contributor.author | Kandoth, Cyriac | - |
dc.contributor.author | Fulton, Robert | - |
dc.contributor.author | Fulton, Lucinda L. | - |
dc.contributor.author | McLellan, Michael D. | - |
dc.contributor.author | Wilson, Richard K. | - |
dc.contributor.author | Ye, Kai | - |
dc.contributor.author | Fronick, Catrina C. | - |
dc.contributor.author | Maher, Christopher A. | - |
dc.contributor.author | Miller, Christopher A. | - |
dc.contributor.author | Wendl, Michael C. | - |
dc.contributor.author | Cabanski, Christopher | - |
dc.contributor.author | Mardis, Elaine | - |
dc.contributor.author | Wheeler, David | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Hirst, Carrie | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Varhol, Richard | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Wye, Natasja | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Imielinski, Marcin | - |
dc.contributor.author | Onofrio, Robert C. | - |
dc.contributor.author | Hodis, Eran | - |
dc.contributor.author | Zack, Travis | - |
dc.contributor.author | Helman, Elena | - |
dc.contributor.author | Pedamallu, Chandra Sekhar | - |
dc.contributor.author | Mesirov, Jill | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Garraway, Levi | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Chen, Peng-Chieh | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Xu, Andrew Wei | - |
dc.contributor.author | Santoso, Netty | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Veluvolu, Umadevi | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Soloway, Matthew G. | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Roach, Jeffrey | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Singh, Darshan | - |
dc.contributor.author | Prins, Jan F. | - |
dc.contributor.author | Marron, J. S. | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Liu, Jinze | - |
dc.contributor.author | Maglinte, Dennis T. | - |
dc.contributor.author | Lai, Philip H. | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | Van Den Berg, David J. | - |
dc.contributor.author | Triche, Timothy, Jr. | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Heiman, David | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Mallard, William | - |
dc.contributor.author | Voet, Douglas | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zou, Lihua | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Thorvaldsdottir, Helga | - |
dc.contributor.author | Nazaire, Marc-Danie | - |
dc.contributor.author | Robinson, Jim | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Dresdner, Gideon | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Seshan, Venkatraman E. | - |
dc.contributor.author | Reva, Boris | - |
dc.contributor.author | Sumer, S. Onur | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Sam Ng | - |
dc.contributor.author | Zhu, Jingchun | - |
dc.contributor.author | Benz, Christopher C. | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Spellman, Paul T. | - |
dc.contributor.author | Kimes, Patrick K. | - |
dc.contributor.author | Broom, Bradley M. | - |
dc.contributor.author | Wang, Jing | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Patrick Kwok Shing Ng | - |
dc.contributor.author | Diao, Lixia | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Amos, Christopher I. | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Paulauskis, Joseph | - |
dc.contributor.author | Lau, Kevin | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Gardner, Johanna | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Saller, Charles | - |
dc.contributor.author | Tarvin, Katherine | - |
dc.contributor.author | Richards, William G. | - |
dc.contributor.author | Cerfolio, Robert | - |
dc.contributor.author | Bryant, Ayesha | - |
dc.contributor.author | Raymond, Daniel P. | - |
dc.contributor.author | Pennell, Nathan A. | - |
dc.contributor.author | Farver, Carol | - |
dc.contributor.author | Czerwinski, Christine | - |
dc.contributor.author | Huelsenbeck-Dill, Lori | - |
dc.contributor.author | Iacocca, Mary | - |
dc.contributor.author | Petrelli, Nicholas | - |
dc.contributor.author | Rabeno, Brenda | - |
dc.contributor.author | Brown, Jennifer | - |
dc.contributor.author | Bauer, Thomas | - |
dc.contributor.author | Dolzhanskiy, Oleg | - |
dc.contributor.author | Potapova, Olga | - |
dc.contributor.author | Rotin, Daniil | - |
dc.contributor.author | Voronina, Olga | - |
dc.contributor.author | Nemirovich-Danchenko, Elena | - |
dc.contributor.author | Fedosenko, Konstantin V. | - |
dc.contributor.author | Gal, Anthony | - |
dc.contributor.author | Behera, Madhusmita | - |
dc.contributor.author | Ramalingam, Suresh S. | - |
dc.contributor.author | Sica, Gabriel | - |
dc.contributor.author | Flieder, Douglas | - |
dc.contributor.author | Boyd, Jeff | - |
dc.contributor.author | Weaver, JoEllen | - |
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dc.contributor.author | Dang Huy Quoc Thinh | - |
dc.contributor.author | Sandusky, George | - |
dc.contributor.author | Juhl, Hartmut | - |
dc.contributor.author | Duhig, Edwina | - |
dc.contributor.author | Illei, Peter | - |
dc.contributor.author | Gabrielson, Edward | - |
dc.contributor.author | Shin, James | - |
dc.contributor.author | Lee, Beverly | - |
dc.contributor.author | Rogers, Kristen | - |
dc.contributor.author | Trusty, Dante | - |
dc.contributor.author | Brock, Malcolm V. | - |
dc.contributor.author | Williamson, Christina | - |
dc.contributor.author | Burks, Eric | - |
dc.contributor.author | Rieger-Christ, Kimberly | - |
dc.contributor.author | Holway, Antonia | - |
dc.contributor.author | Sullivan, Travis | - |
dc.contributor.author | Asiedu, Michael K. | - |
dc.contributor.author | Kosari, Farhad | - |
dc.contributor.author | Rekhtman, Natasha | - |
dc.contributor.author | Zakowski, Maureen | - |
dc.contributor.author | Rusch, Valerie W. | - |
dc.contributor.author | Zippile, Paul | - |
dc.contributor.author | Suh, James | - |
dc.contributor.author | Pass, Harvey | - |
dc.contributor.author | Goparaju, Chandra | - |
dc.contributor.author | Owusu-Sarpong, Yvonne | - |
dc.contributor.author | Bartlett, John M. S. | - |
dc.contributor.author | Kodeeswaran, Sugy | - |
dc.contributor.author | Parfitt, Jeremy | - |
dc.contributor.author | Sekhon, Harmanjatinder | - |
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dc.contributor.author | Eckman, John | - |
dc.contributor.author | Myers, Jerome B. | - |
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dc.contributor.author | Morrison, Carl | - |
dc.contributor.author | Gaudioso, Carmelo | - |
dc.contributor.author | Borgia, Jeffrey A. | - |
dc.contributor.author | Bonomi, Philip | - |
dc.contributor.author | Pool, Mark | - |
dc.contributor.author | Liptay, Michael J. | - |
dc.contributor.author | Moiseenko, Fedor | - |
dc.contributor.author | Zaytseva, Irina | - |
dc.contributor.author | Dienemann, Hendrik | - |
dc.contributor.author | Meister, Michael | - |
dc.contributor.author | Schnabel, Philipp A. | - |
dc.contributor.author | Muley, Thomas R. | - |
dc.contributor.author | Peifer, Martin | - |
dc.contributor.author | Gomez-Fernandez, Carmen | - |
dc.contributor.author | Herbert, Lynn | - |
dc.contributor.author | Egea, Sophie | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Thorne, Leigh B. | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Salazar, Ashley Hill | - |
dc.contributor.author | Funkhouser, William K. | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Yousem, Samuel A. | - |
dc.contributor.author | Dacic, Sanja | - |
dc.contributor.author | Schneider, Frank | - |
dc.contributor.author | Siegfried, Jill M. | - |
dc.contributor.author | Hajek, Richard | - |
dc.contributor.author | Watson, Mark A. | - |
dc.contributor.author | McDonald, Sandra | - |
dc.contributor.author | Meyers, Bryan | - |
dc.contributor.author | Clarke, Belinda | - |
dc.contributor.author | Yang, Ian A. | - |
dc.contributor.author | Fong, Kwun M. | - |
dc.contributor.author | Hunter, Lindy | - |
dc.contributor.author | Windsor, Morgan | - |
dc.contributor.author | Bowman, Rayleen V. | - |
dc.contributor.author | Peters, Solange | - |
dc.contributor.author | Letovanec, Igor | - |
dc.contributor.author | Khan, Khurram Z. | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Snyder, Eric E. | - |
dc.contributor.author | Srinivasan, Deepak | - |
dc.contributor.author | Kahn, Ari B. | - |
dc.contributor.author | Baboud, Julien | - |
dc.contributor.author | Pot, David A. | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Zenklusen, Jean Claude | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.date.accessioned | 2023-12-22T02:36:31Z | - |
dc.date.available | 2023-12-22T02:36:31Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2014-07 | - |
dc.description.abstract | Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis | - |
dc.identifier.bibliographicCitation | NATURE, v.511, no.7511, pp.543 - 550 | - |
dc.identifier.doi | 10.1038/nature13385 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18883 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v511/n7511/full/nature13385.html | - |
dc.identifier.wosid | 000339566300025 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive molecular profiling of lung adenocarcinoma | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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