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DC Field | Value | Language |
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dc.citation.endPage | 209 | - |
dc.citation.number | 7517 | - |
dc.citation.startPage | 202 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 513 | - |
dc.contributor.author | Bass, Adam J. | - |
dc.contributor.author | Thorsson, Vesteinn | - |
dc.contributor.author | Shmulevich, Ilya | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Miller, Michael | - |
dc.contributor.author | Bernard, Brady | - |
dc.contributor.author | Hinoue, Toshinori | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Curtis, Christina | - |
dc.contributor.author | Shen, Hui | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Keiser, David P. | - |
dc.contributor.author | Bowlby, Reanne | - |
dc.contributor.author | Sipahimalani, Payal | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Liu, Yingchun | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | Pedamallu, Chandra | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Taylor-Weiner, Amaro | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Lee, Ju-Seog | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Yang, Da | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Gulley, Margaret | - |
dc.contributor.author | Piazuelo, M. Blanca | - |
dc.contributor.author | Schneider, Barbara G. | - |
dc.contributor.author | Kim, Jihun | - |
dc.contributor.author | Boussioutas, Alex | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Rabkin, Charles S. | - |
dc.contributor.author | Willis, Joseph E. | - |
dc.contributor.author | Ng, Sam | - |
dc.contributor.author | Garman, Katherine | - |
dc.contributor.author | Beer, David G. | - |
dc.contributor.author | Pennathur, Arjun | - |
dc.contributor.author | Raphael, Benjamin J. | - |
dc.contributor.author | Wu, Hsin-Ta | - |
dc.contributor.author | Odze, Robert | - |
dc.contributor.author | Kim, Hark K. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Leraas, Kristen M. | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | Weaver, Lichtenberg | - |
dc.contributor.author | McLellan, Michael | - |
dc.contributor.author | Wiznerowicz, Maciej | - |
dc.contributor.author | Sakai, Ryo | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Lichtenstein, Lee | - |
dc.contributor.author | Fisher, Sheila | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Lander, Eric S. | - |
dc.contributor.author | Ding, Li | - |
dc.contributor.author | Niu, Beifang | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Birol, Inanc | - |
dc.contributor.author | Brooks, Denise | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chu, Justin | - |
dc.contributor.author | Chuah, Eric | - |
dc.contributor.author | Chun, Hye-Jung E. | - |
dc.contributor.author | Clarke, Amanda | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Kasaian, Katayoon | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan A. | - |
dc.contributor.author | Lim, Emilia | - |
dc.contributor.author | Ma, Yussanne | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Mungall, Karen L. | - |
dc.contributor.author | Nip, Ka Ming | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Heiman, David I. | - |
dc.contributor.author | Jung, Joonil | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Ojesina, Akinyemi I. | - |
dc.contributor.author | Pedamallu, Chandra Sekhar | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | Tabak, Barbara | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Rosenberg, Mara | - |
dc.contributor.author | Zack, Travis I. | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zou, Lihua | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Santoso, Netty | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Tang, Jiabin | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Xu, Andrew W. | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Xi, Ruibin | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Seidman, Jonathan | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Ling, Shiyun | - |
dc.contributor.author | Rao, Arvind | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Kim, Sang-Bae | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Mills, Gordon | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | Lai, Phillip H. | - |
dc.contributor.author | Triche, Timothy, Jr. | - |
dc.contributor.author | Van Den Berg, David J. | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Murray, Bradley A. | - |
dc.contributor.author | Askoy, B. Arman | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Dresdner, Gideon | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Lee, William | - |
dc.contributor.author | Ramirez, Ricardo | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Senbabaoglu, Yasin | - |
dc.contributor.author | Sinha, Rileen | - |
dc.contributor.author | Sumer, S. Onur | - |
dc.contributor.author | Sun, Yichao | - |
dc.contributor.author | Iype, Lisa | - |
dc.contributor.author | Kramer, Roger W. | - |
dc.contributor.author | Kreisberg, Richard | - |
dc.contributor.author | Rovira, Hector | - |
dc.contributor.author | Tasman, Natalie | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Stuart, Josh M. | - |
dc.contributor.author | Verhaak, Roeland G. W. | - |
dc.contributor.author | Leiserson, Mark D. M. | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Black, Aaron D. | - |
dc.contributor.author | Carney, Julie Ann | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Helsel, Carmen | - |
dc.contributor.author | McAllister, Cynthia | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Tabler, Teresa R. | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Zmuda, Erik | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Crain, Daniel | - |
dc.contributor.author | Gardner, Johanna | - |
dc.contributor.author | Lau, Kevin | - |
dc.contributor.author | Curely, Erin | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Paulauskis, Joseph | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Shelton, Candace | - |
dc.contributor.author | Sherman, Mark | - |
dc.contributor.author | Benz, Christopher | - |
dc.contributor.author | Lee, Jae-Hyuk | - |
dc.contributor.author | Fedosenko, Konstantin | - |
dc.contributor.author | Manikhas, Georgy | - |
dc.contributor.author | Voronina, Olga | - |
dc.contributor.author | Belyaev, Dmitry | - |
dc.contributor.author | Dolzhansky, Oleg | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Brzezinski, Jakub | - |
dc.contributor.author | Ibbs, Matthew | - |
dc.contributor.author | Korski, Konstanty | - |
dc.contributor.author | Kycler, Witold | - |
dc.contributor.author | Lazniak, Radoslaw | - |
dc.contributor.author | Leporowska, Ewa | - |
dc.contributor.author | Mackiewicz, Andrzej | - |
dc.contributor.author | Murawa, Dawid | - |
dc.contributor.author | Murawa, Pawel | - |
dc.contributor.author | Spychala, Arkadiusz | - |
dc.contributor.author | Suchorska, Wiktoria M. | - |
dc.contributor.author | Tatka, Honorata | - |
dc.contributor.author | Teresiak, Marek | - |
dc.contributor.author | Abdel-Misih, Raafat | - |
dc.contributor.author | Bennett, Joseph | - |
dc.contributor.author | Brown, Jennifer | - |
dc.contributor.author | Iacocca, Mary | - |
dc.contributor.author | Rabeno, Brenda | - |
dc.contributor.author | Kwon, Sun-Young | - |
dc.contributor.author | Kemkes, Ariane | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Alexopoulou, Iakovina | - |
dc.contributor.author | Engel, Jay | - |
dc.contributor.author | Bartlett, John | - |
dc.contributor.author | Albert, Monique | - |
dc.contributor.author | Park, Do-Youn | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | Luketich, James | - |
dc.contributor.author | Landreneau, Rodney | - |
dc.contributor.author | Janjigian, Yelena Y. | - |
dc.contributor.author | Kelsen, David P. | - |
dc.contributor.author | Cho, Eunjung | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Tang, Laura | - |
dc.contributor.author | McCall, Shannon J. | - |
dc.contributor.author | Park, Young S. | - |
dc.contributor.author | Cheong, Jae-Ho | - |
dc.contributor.author | Ajani, Jaffer | - |
dc.contributor.author | Camargo, M. Constanza | - |
dc.contributor.author | Alonso, Shelley | - |
dc.contributor.author | Ayala, Brenda | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Pihl, Todd | - |
dc.contributor.author | Raman, Rohini | - |
dc.contributor.author | Walton, Jessica | - |
dc.contributor.author | Wan, Yunhu | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Zenklusen, Jean Claude | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Hutter, Carolyn M. | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Burton, Robert | - |
dc.contributor.author | Chudamani, Sudha | - |
dc.contributor.author | Liu, Jia | - |
dc.date.accessioned | 2023-12-22T02:11:39Z | - |
dc.date.available | 2023-12-22T02:11:39Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2014-09 | - |
dc.description.abstract | Gastric cancer is a leading cause of cancer deaths, but analysis of molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roalmap for patient stratification and trials of targeted therapies | - |
dc.identifier.bibliographicCitation | NATURE, v.513, no.7517, pp.202 - 209 | - |
dc.identifier.doi | 10.1038/nature13480 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18881 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v513/n7517/full/nature13480.html | - |
dc.identifier.wosid | 000341362800044 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive molecular characterization of gastric adenocarcinoma | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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