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DC Field | Value | Language |
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dc.citation.endPage | 582 | - |
dc.citation.number | 7536 | - |
dc.citation.startPage | 576 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 517 | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Lichtenstein, Lee | - |
dc.contributor.author | Cibulskisl, Kristian | - |
dc.contributor.author | Lander, Eric | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Biroi, Inanc | - |
dc.contributor.author | Bowlby, Reanne | - |
dc.contributor.author | Brooks, Denise | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Carlsen, Rebecca | - |
dc.contributor.author | Cheng, Dean | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Sipahimalan, Payal | - |
dc.contributor.author | Tam, Angela | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Wong, Tina | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Santoso, Netty | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Tang, Jiabin | - |
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dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Haseley, Psalm | - |
dc.contributor.author | Zeng, Dong | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Xu, Andrew W. | - |
dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Hadjipanayis, Angela | - |
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dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Casasent, Tod | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Le, Yiling | - |
dc.contributor.author | Mille, Gordon | - |
dc.contributor.author | Motter, Thomas | - |
dc.contributor.author | Weinstein, John | - |
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dc.contributor.author | Wang, Jing | - |
dc.contributor.author | Fan, You Hong | - |
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dc.contributor.author | Wang, Kai | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Bodenheimer, Thomas | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Jones, Corbin D. | - |
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dc.contributor.author | Liu, Yufeng | - |
dc.contributor.author | Marron, J. S. | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Prins, Jan F. | - |
dc.contributor.author | Roach, Jeffrey | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Singh, Darshan | - |
dc.contributor.author | Soloway, Matthew G. | - |
dc.contributor.author | Tan, Donghui | - |
dc.contributor.author | Veluvolu, Umadevi | - |
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dc.contributor.author | Waring, Scot | - |
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dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Hammerman, Peter S. | - |
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dc.contributor.author | Pedamallu, Chandra Sekhar | - |
dc.contributor.author | Saksena, Gordon | - |
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dc.contributor.author | Ojesina, Akinyemi I. | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Zack, Travis I. | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Freeman, Samuel S. | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Heiman, David I. | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Voet, Doug | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Stojanov, Petar | - |
dc.contributor.author | Liu, Yingchun | - |
dc.contributor.author | Zou, Lihua | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Muzny, Donna | - |
dc.contributor.author | Doddapaneni, HarshaVardhan | - |
dc.contributor.author | Kovar, Christie | - |
dc.contributor.author | Reid, Jeff | - |
dc.contributor.author | Morton, Donna | - |
dc.contributor.author | Han, Yi | - |
dc.contributor.author | Hale, Walker | - |
dc.contributor.author | Chao, Hsu | - |
dc.contributor.author | Chang, Kyle | - |
dc.contributor.author | Drummond, Jennifer A. | - |
dc.contributor.author | Gibbs, Richard A. | - |
dc.contributor.author | Kakkar, Nipun | - |
dc.contributor.author | Wheeler, David | - |
dc.contributor.author | Xi, Liu | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Lee, William | - |
dc.contributor.author | Ramirez, Ricardo | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Sinhal, Rileen | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Taylor, Barry S. | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Dresdner, Gideon | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Reva, Boris | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Sumer, S. Onur | - |
dc.contributor.author | Sun, Yichao | - |
dc.contributor.author | Chan, Timothy A. | - |
dc.contributor.author | Morris, Luc G. | - |
dc.contributor.author | Stuart, Joshua | - |
dc.contributor.author | Benz, Stephen | - |
dc.contributor.author | Ng, Sam | - |
dc.contributor.author | Benz, Christopher | - |
dc.contributor.author | Yau, Christina | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Cope, Leslie | - |
dc.contributor.author | Danilova, Ludmila | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Bootwalla, Moiz | - |
dc.contributor.author | Maglinte, Dennis T. | - |
dc.contributor.author | Larid, Peter W. | - |
dc.contributor.author | Triche, Timothy, Jr. | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | Van den Berg, David J. | - |
dc.contributor.author | Agrawal, Nishant | - |
dc.contributor.author | Bishop, Justin | - |
dc.contributor.author | Boutros, Paul C. | - |
dc.contributor.author | Bruce, Jeff P. | - |
dc.contributor.author | Byers, Lauren Averett | - |
dc.contributor.author | Califano, Joseph | - |
dc.contributor.author | Carey, Thomas E. | - |
dc.contributor.author | Chen, Zhong | - |
dc.contributor.author | Cheng, Hui | - |
dc.contributor.author | Chiosea, Simion I. | - |
dc.contributor.author | Cohen, Ezra | - |
dc.contributor.author | Diergaarde, Brenda | - |
dc.contributor.author | Egloff, Ann Marie | - |
dc.contributor.author | El-Naggar, Adel K. | - |
dc.contributor.author | Ferris, Robert L. | - |
dc.contributor.author | Frederick, Mitchell J. | - |
dc.contributor.author | Grandis, Jennifer R. | - |
dc.contributor.author | Guo, Yan | - |
dc.contributor.author | Haddad, Robert I. | - |
dc.contributor.author | Harris, Thomas | - |
dc.contributor.author | Hui, Angela B. Y. | - |
dc.contributor.author | Lee, J. Jack | - |
dc.contributor.author | Lippman, Scott M. | - |
dc.contributor.author | Liu, Fei-Fei | - |
dc.contributor.author | McHugh, Jonathan B. | - |
dc.contributor.author | Myers, Jeff | - |
dc.contributor.author | Ng, Patrick Kwok Shing | - |
dc.contributor.author | Perez-Ordonez, Bayardo | - |
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dc.contributor.author | Prystowsky, Michael | - |
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dc.contributor.author | Seethala, Raja | - |
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dc.contributor.author | Waggott, Daryl M. | - |
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dc.contributor.author | Morris, Scott | - |
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dc.contributor.author | Yena, Peggy | - |
dc.contributor.author | Black, Aaron D. | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Frick, Jessica | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Harper, Hollie A. | - |
dc.contributor.author | Leraas, Kristen | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Zmuda, Erik | - |
dc.contributor.author | Baboud, Julien | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Kahn, An B. | - |
dc.contributor.author | Pihl, Todd D. | - |
dc.contributor.author | Pot, David A. | - |
dc.contributor.author | Srinivasan, Deepak | - |
dc.contributor.author | Walton, Jessica S. | - |
dc.contributor.author | Wan, Yunhu | - |
dc.contributor.author | Burton, Robert A. | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Ferguson, Martin L. | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Sofia, Heidi J. | - |
dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Zenklusen, Jean Claude | - |
dc.contributor.author | Saller, Charles | - |
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dc.contributor.author | Chen, Chu | - |
dc.contributor.author | Bollag, Roni | - |
dc.contributor.author | Weinberger, Paul | - |
dc.contributor.author | Golusinski, Wojciech | - |
dc.contributor.author | Golusinski, Pawel | - |
dc.contributor.author | Ibbs, Matthew | - |
dc.contributor.author | Korski, Konstanty | - |
dc.contributor.author | Mackiewicz, Andrzej | - |
dc.contributor.author | Suchorska, Wiktoria | - |
dc.contributor.author | Szybiak, Bartosz | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Beard, Christina | - |
dc.contributor.author | Mitchell, Colleen | - |
dc.contributor.author | Sandusky, George | - |
dc.contributor.author | Ahn, Julie | - |
dc.contributor.author | Khan, Zubair | - |
dc.contributor.author | Irish, Jonathan | - |
dc.contributor.author | Waldron, John | - |
dc.contributor.author | William, William N., Jr. | - |
dc.contributor.author | Egea, Sophie | - |
dc.contributor.author | Gomez-Fernandez, Carmen | - |
dc.contributor.author | Herbert, Lynn | - |
dc.contributor.author | Bradford, Carol R. | - |
dc.contributor.author | Chepeha, Douglas B. | - |
dc.contributor.author | Haddad, Andrea S. | - |
dc.contributor.author | Jones, Tamara R. | - |
dc.contributor.author | Komarck, Christine M. | - |
dc.contributor.author | Malakh, Mayya | - |
dc.contributor.author | Moyer, Jeffrey S. | - |
dc.contributor.author | Nguyen, Ariane | - |
dc.contributor.author | Peterson, Lisa A. | - |
dc.contributor.author | Prince, Mark E. | - |
dc.contributor.author | Rozek, Laura S. | - |
dc.contributor.author | Taylor, Evan G. | - |
dc.contributor.author | Walline, Heather M. | - |
dc.contributor.author | Wolf, Gregory T. | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Chera, Bhishamjit S. | - |
dc.contributor.author | Funkhouser, William K. | - |
dc.contributor.author | Gulley, Margaret L. | - |
dc.contributor.author | Hackman, Trevor G. | - |
dc.contributor.author | Hayward, Michele C. | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Salazar, Ashley H. | - |
dc.contributor.author | Shockley, William W. | - |
dc.contributor.author | Shores, Carol G. | - |
dc.contributor.author | Thorne, Leigh | - |
dc.contributor.author | Weissler, Mark C. | - |
dc.contributor.author | Wrenn, Sylvia | - |
dc.contributor.author | Zanation, Adam M. | - |
dc.contributor.author | Brown, Brandee T. | - |
dc.contributor.author | Pham, Michelle | - |
dc.date.accessioned | 2023-12-22T01:42:24Z | - |
dc.date.available | 2023-12-22T01:42:24Z | - |
dc.date.created | 2016-03-28 | - |
dc.date.issued | 2015-01 | - |
dc.description.abstract | The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs | - |
dc.identifier.bibliographicCitation | NATURE, v.517, no.7536, pp.576 - 582 | - |
dc.identifier.doi | 10.1038/nature14129 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18877 | - |
dc.identifier.url | http://www.nature.com/nature/journal/v517/n7536/full/nature14129.html | - |
dc.identifier.wosid | 000348775000035 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Comprehensive genomic characterization of head and neck squamous cell carcinomas | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GROWTH-FACTOR-RECEPTOR | - |
dc.subject.keywordPlus | AJUBA FAMILY PROTEINS | - |
dc.subject.keywordPlus | CANCER GROWTH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRAF3 | - |
dc.subject.keywordPlus | EGFR | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | RESISTANCE | - |
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