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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 19213 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 19208 | - |
dc.citation.title | RSC ADVANCES | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Kim, Hansol | - |
dc.contributor.author | Kang, Young Ji | - |
dc.contributor.author | Min, Junseon | - |
dc.contributor.author | Choi, Hyeokjune | - |
dc.contributor.author | Kang, Sebyung | - |
dc.date.accessioned | 2023-12-22T00:09:49Z | - |
dc.date.available | 2023-12-22T00:09:49Z | - |
dc.date.created | 2016-03-15 | - |
dc.date.issued | 2016-02 | - |
dc.description.abstract | A polyvalent antibody-binding lumazine synthase protein cage nanoparticle (ABD-AaLS) is constructed by genetically fusing lumazine synthase and antibody-binding domains. ABD-AaLS effectively captures targeting antibodies in an orientation-controlled manner by selectively binding to the Fc region of antibodies derived from a variety of species, such as rabbits, rats, and mice, on demand by simple molecular recognition. The resulting antibody/ABD-AaLS non-covalent complexes specifically recognize and bind to their target cells in vitro, guided by antibodies displayed on the surface of ABD-AaLS. ABD-AaLS has an additional internal cavity and exterior sites for encapsulation and attachment of cargo molecules such as drugs and diagnostic probes. ABD-AaLS effectively serves as a universal antibody-binding nanoplatform to display various targeting antibodies on demand through molecular recognition as well as to acquire additional functionalities without altering the essential properties of the targeting antibodies. ABD-AaLS may provide new opportunities to develop versatile target-dependent nanoscale theranostic systems | - |
dc.identifier.bibliographicCitation | RSC ADVANCES, v.6, no.23, pp.19208 - 19213 | - |
dc.identifier.doi | 10.1039/c6ra00233a | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.scopusid | 2-s2.0-84958963459 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18851 | - |
dc.identifier.url | http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA00233A#!divAbstract | - |
dc.identifier.wosid | 000370710500053 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Development of an antibody-binding modular nanoplatform for antibody-guided targeted cell imaging and delivery | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PROTEIN CAGE NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | LUMAZINE SYNTHASE | - |
dc.subject.keywordPlus | CRYSTALLOGRAPHIC REFINEMENT | - |
dc.subject.keywordPlus | AQUIFEX-AEOLICUS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
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