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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Intrinsic features of the CD8 alpha(-) dendritic cell subset in inducing functional T follicular helper cells

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Title
Intrinsic features of the CD8 alpha(-) dendritic cell subset in inducing functional T follicular helper cells
Author
Shin, ChangsikHan, Jae-AChoi, BongseoCho, Yoon-KyoungDo, YoonkyungRyu, Seongho
Keywords
Cellular immunity; Cytokine; Dendritic cell subset; Humoral immunity; Localization; T follicular helper cell
Issue Date
201604
Publisher
ELSEVIER SCIENCE BV
Citation
IMMUNOLOGY LETTERS, v.172, no., pp.21 - 28
Abstract
T follicular helper (Tfh) cells, a true B cell helper, have a critical role in enhancing humoral immune responses. However, the initial differentiation of Tfh cells by dendritic cells (DCs), the most potent antigen presenting cells, has not been clearly understood, particularly in the knowledge of the two major conventional dendritic cell subsets, CD8α+ DCs or CD8α- DCs. Here we demonstrated that the localization of CD8α- DCs in the marginal zone (MZ) bridging channels is closely associated with the induction of CXCR5+CCR7low Tfh cells. We also showed that the major source of IL-6 for inducing Tfh cells is provided from the activated CD4+ T cells induced by CD8α- DCs, and IL-6 directly secreted from the DC subsets seems minor. CD8α- DCs were superior in inducing functional Tfh cells over other antigen presenting cells including B cells. We here observed the unknown intrinsic features of the DC subsets, suggesting the potential of utilizing the CD8α- DC subset as therapeutic vaccine for the regulation of humoral immune responses. © 2016 The Authors
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DOI
http://dx.doi.org/10.1016/j.imlet.2016.01.009
ISSN
0165-2478
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