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DC Field | Value | Language |
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dc.citation.endPage | 1696 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1681 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 161 | - |
dc.contributor.author | Akbani, Rehan | - |
dc.contributor.author | Akdemir, Kadir C. | - |
dc.contributor.author | Aksoy, B. Arman | - |
dc.contributor.author | Albert, Monique | - |
dc.contributor.author | Ally, Adrian | - |
dc.contributor.author | Amin, Samirkumar B. | - |
dc.contributor.author | Arachchi, Harindra | - |
dc.contributor.author | Arora, Arshi | - |
dc.contributor.author | Auman, J. Todd | - |
dc.contributor.author | Ayala, Brenda | - |
dc.contributor.author | Baboud, Julien | - |
dc.contributor.author | Balasundaram, Miruna | - |
dc.contributor.author | Balu, Saianand | - |
dc.contributor.author | Barnabas, Nandita | - |
dc.contributor.author | Bartlett, John | - |
dc.contributor.author | Bartlett, Pam | - |
dc.contributor.author | Bastian, Boris C. | - |
dc.contributor.author | Baylin, Stephen B. | - |
dc.contributor.author | Behera, Madhusmita | - |
dc.contributor.author | Belyaev, Dmitry | - |
dc.contributor.author | Benz, Christopher | - |
dc.contributor.author | Bernard, Brady | - |
dc.contributor.author | Beroukhim, Rameen | - |
dc.contributor.author | Bir, Natalie | - |
dc.contributor.author | Black, Aaron D. | - |
dc.contributor.author | Bodenheimer, Tom | - |
dc.contributor.author | Boice, Lori | - |
dc.contributor.author | Boland, Genevieve M. | - |
dc.contributor.author | Bono, Riccardo | - |
dc.contributor.author | Bootwalla, Moiz S. | - |
dc.contributor.author | Bosenberg, Marcus | - |
dc.contributor.author | Bowen, Jay | - |
dc.contributor.author | Bowlby, Reanne | - |
dc.contributor.author | Bristow, Christopher A. | - |
dc.contributor.author | Brockway-Lunardi, Laura | - |
dc.contributor.author | Brooks, Denise | - |
dc.contributor.author | Brzezinski, Jakub | - |
dc.contributor.author | Bshara, Wiam | - |
dc.contributor.author | Buda, Elizabeth | - |
dc.contributor.author | Burns, William R. | - |
dc.contributor.author | Butterfield, Yaron S. N. | - |
dc.contributor.author | Button, Michael | - |
dc.contributor.author | Calderone, Tiffany | - |
dc.contributor.author | Cappellini, Giancarlo Antonini | - |
dc.contributor.author | Carter, Candace | - |
dc.contributor.author | Carter, Scott L. | - |
dc.contributor.author | Cherney, Lynn | - |
dc.contributor.author | Cherniack, Andrew D. | - |
dc.contributor.author | Chevalier, Aaron | - |
dc.contributor.author | Chin, Lynda | - |
dc.contributor.author | Cho, Juok | - |
dc.contributor.author | Cho, Raymond J. | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Chu, Andy | - |
dc.contributor.author | Chudamani, Sudha | - |
dc.contributor.author | Cibulskis, Kristian | - |
dc.contributor.author | Ciriello, Giovanni | - |
dc.contributor.author | Clarke, Amanda | - |
dc.contributor.author | Coons, Stephen | - |
dc.contributor.author | Cope, Leslie | - |
dc.contributor.author | Crain, Daniel | - |
dc.contributor.author | Curley, Erin | - |
dc.contributor.author | Danilova, Ludmila | - |
dc.contributor.author | D'Atri, Stefania | - |
dc.contributor.author | Davidsen, Tanja | - |
dc.contributor.author | Davies, Michael A. | - |
dc.contributor.author | Delman, Keith A. | - |
dc.contributor.author | Demchok, John A. | - |
dc.contributor.author | Deng, Qixia A. | - |
dc.contributor.author | Deribe, Yonathan Lissanu | - |
dc.contributor.author | Dhalla, Noreen | - |
dc.contributor.author | Dhir, Rajiv | - |
dc.contributor.author | DiCara, Daniel | - |
dc.contributor.author | Dinikin, Michael | - |
dc.contributor.author | Dubina, Michael | - |
dc.contributor.author | Ebrom, J. Stephen | - |
dc.contributor.author | Egea, Sophie | - |
dc.contributor.author | Eley, Greg | - |
dc.contributor.author | Engel, Jay | - |
dc.contributor.author | Eschbacher, Jennifer M. | - |
dc.contributor.author | Fedosenko, Konstantin V. | - |
dc.contributor.author | Felau, Ina | - |
dc.contributor.author | Fennell, Timothy | - |
dc.contributor.author | Ferguson, Martin L. | - |
dc.contributor.author | Fisher, Sheila | - |
dc.contributor.author | Flaherty, Keith T. | - |
dc.contributor.author | Frazer, Scott | - |
dc.contributor.author | Frick, Jessica | - |
dc.contributor.author | Fulidou, Victoria | - |
dc.contributor.author | Gabriel, Stacey B. | - |
dc.contributor.author | Gao, Jianjiong | - |
dc.contributor.author | Gardner, Johanna | - |
dc.contributor.author | Garraway, Levi A. | - |
dc.contributor.author | Gastier-Foster, Julie M. | - |
dc.contributor.author | Gaudioso, Carmelo | - |
dc.contributor.author | Gehlenborg, Nils | - |
dc.contributor.author | Genovese, Giannicola | - |
dc.contributor.author | Gerken, Mark | - |
dc.contributor.author | Gershenwald, Jeffrey E. | - |
dc.contributor.author | Getz, Gad | - |
dc.contributor.author | Gomez-Fernandez, Carmen | - |
dc.contributor.author | Gribbin, Thomas | - |
dc.contributor.author | Grimsby, Jonna | - |
dc.contributor.author | Gross, Benjamin | - |
dc.contributor.author | Guin, Ranabir | - |
dc.contributor.author | Gutschner, Tony | - |
dc.contributor.author | Hadjipanayis, Angela | - |
dc.contributor.author | Halaban, Ruth | - |
dc.contributor.author | Hanf, Benjamin | - |
dc.contributor.author | Haussler, David | - |
dc.contributor.author | Haydu, Lauren E. | - |
dc.contributor.author | Hayes, D. Neil | - |
dc.contributor.author | Hayward, Nicholas K. | - |
dc.contributor.author | Heiman, David I. | - |
dc.contributor.author | Herbert, Lynn | - |
dc.contributor.author | Herman, James G. | - |
dc.contributor.author | Hersey, Peter | - |
dc.contributor.author | Hoadley, Katherine A. | - |
dc.contributor.author | Hodis, Eran | - |
dc.contributor.author | Holt, Robert A. | - |
dc.contributor.author | Hoon, Dave S. B. | - |
dc.contributor.author | Hoppough, Susan | - |
dc.contributor.author | Hoyle, Alan P. | - |
dc.contributor.author | Huang, Franklin W. | - |
dc.contributor.author | Huang, Mei | - |
dc.contributor.author | Huang, Sharon | - |
dc.contributor.author | Hutter, Carolyn M. | - |
dc.contributor.author | Ibbs, Matthew | - |
dc.contributor.author | Iype, Lisa | - |
dc.contributor.author | Jacobsen, Anders | - |
dc.contributor.author | Jakrot, Valerie | - |
dc.contributor.author | Janning, Alyssa | - |
dc.contributor.author | Jeck, William R. | - |
dc.contributor.author | Jefferys, Stuart R. | - |
dc.contributor.author | Jensen, Mark A. | - |
dc.contributor.author | Jones, Corbin D. | - |
dc.contributor.author | Jones, Steven J. M. | - |
dc.contributor.author | Ju, Zhenlin | - |
dc.contributor.author | Kakavand, Hojabr | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Kefford, Richard F. | - |
dc.contributor.author | Khuri, Fadlo R. | - |
dc.contributor.author | Kim, Jaegil | - |
dc.contributor.author | Kirkwood, John M. | - |
dc.contributor.author | Klode, Joachim | - |
dc.contributor.author | Korkut, Anil | - |
dc.contributor.author | Korski, Konstanty | - |
dc.contributor.author | Krauthammer, Michael | - |
dc.contributor.author | Kucherlapati, Raju | - |
dc.contributor.author | Kwong, Lawrence N. | - |
dc.contributor.author | Kycler, Witold | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Lai, Phillip H. | - |
dc.contributor.author | Laird, Peter W. | - |
dc.contributor.author | Lander, Eric | - |
dc.contributor.author | Lawrence, Michael S. | - |
dc.contributor.author | Lazar, Alexander J. | - |
dc.contributor.author | Qazniak, Radoslaw | - |
dc.contributor.author | Lee, Darlene | - |
dc.contributor.author | Lee, Jeffrey E. | - |
dc.contributor.author | Lee, Junehawk | - |
dc.contributor.author | Lee, Kenneth | - |
dc.contributor.author | Lee, Semin | - |
dc.contributor.author | Lee, William | - |
dc.contributor.author | Leporowska, Ewa | - |
dc.contributor.author | Leraas, Kristen M. | - |
dc.contributor.author | Li, Haiyan I. | - |
dc.contributor.author | Lichtenberg, Tara M. | - |
dc.contributor.author | Lichtenstein, Lee | - |
dc.contributor.author | Lin, Pei | - |
dc.contributor.author | Ling, Shiyun | - |
dc.contributor.author | Liu, Jia | - |
dc.contributor.author | Liu, Ouida | - |
dc.contributor.author | Liu, Wenbin | - |
dc.contributor.author | Long, Georgina V. | - |
dc.contributor.author | Lu, Yiling | - |
dc.contributor.author | Ma, Singer | - |
dc.contributor.author | Ma, Yussanne | - |
dc.contributor.author | Mackiewicz, Andrzej | - |
dc.contributor.author | Mahadeshwar, Harshad S. | - |
dc.contributor.author | Malke, Jared | - |
dc.contributor.author | Mallery, David | - |
dc.contributor.author | Manikhas, Georgy M. | - |
dc.contributor.author | Mann, Graham J. | - |
dc.contributor.author | Marra, Marco A. | - |
dc.contributor.author | Matejka, Brenna | - |
dc.contributor.author | Mayo, Michael | - |
dc.contributor.author | Mehrabi, Sousan | - |
dc.contributor.author | Meng, Shaowu | - |
dc.contributor.author | Meyerson, Matthew | - |
dc.contributor.author | Mieczkowski, Piotr A. | - |
dc.contributor.author | Miller, John P. | - |
dc.contributor.author | Miller, Martin L. | - |
dc.contributor.author | Mills, Gordon B. | - |
dc.contributor.author | Moiseenko, Fedor | - |
dc.contributor.author | Moore, Richard A. | - |
dc.contributor.author | Morris, Scott | - |
dc.contributor.author | Morrison, Carl | - |
dc.contributor.author | Morton, Donald L. | - |
dc.contributor.author | Moschos, Stergios | - |
dc.contributor.author | Mose, Lisle E. | - |
dc.contributor.author | Muller, Florian L. | - |
dc.contributor.author | Mungall, Andrew J. | - |
dc.contributor.author | Murawa, Dawid | - |
dc.contributor.author | Murawa, Pawel | - |
dc.contributor.author | Murray, Bradley A. | - |
dc.contributor.author | Nezi, Luigi | - |
dc.contributor.author | Ng, Sam | - |
dc.contributor.author | Nicholson, Dana | - |
dc.contributor.author | Noble, Michael S. | - |
dc.contributor.author | Osunkoya, Adeboye | - |
dc.contributor.author | Owonikoko, Taofeek K. | - |
dc.contributor.author | Ozenberger, Bradley A. | - |
dc.contributor.author | Pagani, Elena | - |
dc.contributor.author | Paklina, Oxana V. | - |
dc.contributor.author | Pantazi, Angeliki | - |
dc.contributor.author | Parfenov, Michael | - |
dc.contributor.author | Parfitt, Jeremy | - |
dc.contributor.author | Park, Peter J. | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Parker, Joel S. | - |
dc.contributor.author | Passarelli, Francesca | - |
dc.contributor.author | Penny, Robert | - |
dc.contributor.author | Perou, Charles M. | - |
dc.contributor.author | Pihl, Todd D. | - |
dc.contributor.author | Potapova, Olga | - |
dc.contributor.author | Prieto, Victor G. | - |
dc.contributor.author | Protopopov, Alexei | - |
dc.contributor.author | Quinn, Michael J. | - |
dc.contributor.author | Radenbaugh, Amie | - |
dc.contributor.author | Rai, Kunal | - |
dc.contributor.author | Ramalingam, Suresh S. | - |
dc.contributor.author | Raman, Ayush T. | - |
dc.contributor.author | Ramirez, Nilsa C. | - |
dc.contributor.author | Ramirez, Ricardo | - |
dc.contributor.author | Rao, Uma | - |
dc.contributor.author | Rathmell, W. Kimryn | - |
dc.contributor.author | Ren, Xiaojia | - |
dc.contributor.author | Reynolds, Sheila M. | - |
dc.contributor.author | Roach, Jeffrey | - |
dc.contributor.author | Robertson, A. Gordon | - |
dc.contributor.author | Ross, Merrick I. | - |
dc.contributor.author | Roszik, Jason | - |
dc.contributor.author | Russo, Giandomenico | - |
dc.contributor.author | Saksena, Gordon | - |
dc.contributor.author | Saller, Charles | - |
dc.contributor.author | Samuels, Yardena | - |
dc.contributor.author | Sander, Chris | - |
dc.contributor.author | Sander, Cindy | - |
dc.contributor.author | Sandusky, George | - |
dc.contributor.author | Santoso, Netty | - |
dc.contributor.author | Saul, Melissa | - |
dc.contributor.author | Saw, Robyn P. M. | - |
dc.contributor.author | Schadendorf, Dirk | - |
dc.contributor.author | Schein, Jacqueline E. | - |
dc.contributor.author | Schultz, Nikolaus | - |
dc.contributor.author | Schumacher, Steven E. | - |
dc.contributor.author | Schwallier, Charles | - |
dc.contributor.author | Scolyer, Richard A. | - |
dc.contributor.author | Seidman, Jonathan | - |
dc.contributor.author | Sekhar, Pedamallu Chandra | - |
dc.contributor.author | Sekhon, Harmanjatinder S. | - |
dc.contributor.author | Senbabaoglu, Yasin | - |
dc.contributor.author | Seth, Sahil | - |
dc.contributor.author | Shannon, Kerwin F. | - |
dc.contributor.author | Sharpe, Samantha | - |
dc.contributor.author | Sharpless, Norman E. | - |
dc.contributor.author | Shaw, Kenna R. Mills | - |
dc.contributor.author | Shelton, Candace | - |
dc.contributor.author | Shelton, Troy | - |
dc.contributor.author | Shen, Ronglai | - |
dc.contributor.author | Sheth, Margi | - |
dc.contributor.author | Shi, Yan | - |
dc.contributor.author | Shiau, Carolyn J. | - |
dc.contributor.author | Shmulevich, Ilya | - |
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dc.contributor.author | Simons, Janae V. | - |
dc.contributor.author | Sinha, Rileen | - |
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dc.contributor.author | Song, Xingzhi | - |
dc.contributor.author | Sougnez, Carrie | - |
dc.contributor.author | Spillane, Andrew J. | - |
dc.contributor.author | Spychaa, Arkadiusz | - |
dc.contributor.author | Stretch, Jonathan R. | - |
dc.contributor.author | Stuart, Joshua | - |
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dc.contributor.author | Sucker, Antje | - |
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dc.contributor.author | Tabler, Teresa R. | - |
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dc.contributor.author | Tan, Donghui | - |
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dc.contributor.author | Tarnuzzer, Roy | - |
dc.contributor.author | Tarvin, Katherine | - |
dc.contributor.author | Tatka, Honorata | - |
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dc.contributor.author | Teresiak, Marek | - |
dc.contributor.author | Thiessen, Nina | - |
dc.contributor.author | Thompson, John F. | - |
dc.contributor.author | Thorne, Leigh | - |
dc.contributor.author | Thorsson, Vesteinn | - |
dc.contributor.author | Trent, Jeffrey M. | - |
dc.contributor.author | Triche, Timothy J., Jr. | - |
dc.contributor.author | Tsai, Kenneth Y. | - |
dc.contributor.author | Tsou, Peiling | - |
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dc.contributor.author | Van Allen, Eliezer M. | - |
dc.contributor.author | Veluvolu, Umadevi | - |
dc.contributor.author | Verhaak, Roeland G. | - |
dc.contributor.author | Voet, Douglas | - |
dc.contributor.author | Voronina, Olga | - |
dc.contributor.author | Walter, Vonn | - |
dc.contributor.author | Walton, Jessica S. | - |
dc.contributor.author | Wan, Yunhu | - |
dc.contributor.author | Wang, Yuling | - |
dc.contributor.author | Wang, Zhining | - |
dc.contributor.author | Waring, Scot | - |
dc.contributor.author | Watson, Ian R. | - |
dc.contributor.author | Weinhold, Nils | - |
dc.contributor.author | Weinstein, John N. | - |
dc.contributor.author | Weisenberger, Daniel J. | - |
dc.contributor.author | White, Peter | - |
dc.contributor.author | Wilkerson, Matthew D. | - |
dc.contributor.author | Wilmott, James S. | - |
dc.contributor.author | Wise, Lisa | - |
dc.contributor.author | Wiznerowicz, Maciej | - |
dc.contributor.author | Woodman, Scott E. | - |
dc.contributor.author | Wu, Chang-Jiun | - |
dc.contributor.author | Wu, Chia-Chin | - |
dc.contributor.author | Wu, Junyuan | - |
dc.contributor.author | Wu, Ye | - |
dc.contributor.author | Xi, Ruibin | - |
dc.contributor.author | Xu, Andrew Wei | - |
dc.contributor.author | Yang, Da | - |
dc.contributor.author | Yang, Liming | - |
dc.contributor.author | Yang, Lixing | - |
dc.contributor.author | Zack, Travis I. | - |
dc.contributor.author | Zen-Klusen, Jean C. | - |
dc.contributor.author | Zhang, Hailei | - |
dc.contributor.author | Zhang, Jianhua | - |
dc.contributor.author | Zhang, Wei | - |
dc.contributor.author | Zhao, Xiaobei | - |
dc.contributor.author | Zhu, Jingchun | - |
dc.contributor.author | Zhu, Kelsey | - |
dc.contributor.author | Zimmer, Lisa | - |
dc.contributor.author | Zmuda, Erik | - |
dc.contributor.author | Zou, Lihua | - |
dc.date.accessioned | 2023-12-22T01:09:27Z | - |
dc.date.available | 2023-12-22T01:09:27Z | - |
dc.date.created | 2016-03-23 | - |
dc.date.issued | 2015-06 | - |
dc.description.abstract | We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four sub-types based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making | - |
dc.identifier.bibliographicCitation | CELL, v.161, no.7, pp.1681 - 1696 | - |
dc.identifier.doi | 10.1016/j.cell.2015.05.044 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18788 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0092867415006340 | - |
dc.identifier.wosid | 000356618200023 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Genomic Classification of Cutaneous Melanoma | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TERT PROMOTER MUTATIONS | - |
dc.subject.keywordPlus | STAGE-III MELANOMA | - |
dc.subject.keywordPlus | METASTATIC MELANOMA | - |
dc.subject.keywordPlus | ADJUVANT THERAPY | - |
dc.subject.keywordPlus | RAF INHIBITION | - |
dc.subject.keywordPlus | NODE BIOPSY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | LANDSCAPE | - |
dc.subject.keywordPlus | SAFETY | - |
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