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Lee, Semin
Computational Biology Lab.
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Genomic Classification of Cutaneous Melanoma

Author(s)
Akbani, RehanAkdemir, Kadir C.Aksoy, B. ArmanAlbert, MoniqueAlly, AdrianAmin, Samirkumar B.Arachchi, HarindraArora, ArshiAuman, J. ToddAyala, BrendaBaboud, JulienBalasundaram, MirunaBalu, SaianandBarnabas, NanditaBartlett, JohnBartlett, PamBastian, Boris C.Baylin, Stephen B.Behera, MadhusmitaBelyaev, DmitryBenz, ChristopherBernard, BradyBeroukhim, RameenBir, NatalieBlack, Aaron D.Bodenheimer, TomBoice, LoriBoland, Genevieve M.Bono, RiccardoBootwalla, Moiz S.Bosenberg, MarcusBowen, JayBowlby, ReanneBristow, Christopher A.Brockway-Lunardi, LauraBrooks, DeniseBrzezinski, JakubBshara, WiamBuda, ElizabethBurns, William R.Butterfield, Yaron S. N.Button, MichaelCalderone, TiffanyCappellini, Giancarlo AntoniniCarter, CandaceCarter, Scott L.Cherney, LynnCherniack, Andrew D.Chevalier, AaronChin, LyndaCho, JuokCho, Raymond J.Choi, Yoon-LaChu, AndyChudamani, SudhaCibulskis, KristianCiriello, GiovanniClarke, AmandaCoons, StephenCope, LeslieCrain, DanielCurley, ErinDanilova, LudmilaD'Atri, StefaniaDavidsen, TanjaDavies, Michael A.Delman, Keith A.Demchok, John A.Deng, Qixia A.Deribe, Yonathan LissanuDhalla, NoreenDhir, RajivDiCara, DanielDinikin, MichaelDubina, MichaelEbrom, J. StephenEgea, SophieEley, GregEngel, JayEschbacher, Jennifer M.Fedosenko, Konstantin V.Felau, InaFennell, TimothyFerguson, Martin L.Fisher, SheilaFlaherty, Keith T.Frazer, ScottFrick, JessicaFulidou, VictoriaGabriel, Stacey B.Gao, JianjiongGardner, JohannaGarraway, Levi A.Gastier-Foster, Julie M.Gaudioso, CarmeloGehlenborg, NilsGenovese, GiannicolaGerken, MarkGershenwald, Jeffrey E.Getz, GadGomez-Fernandez, CarmenGribbin, ThomasGrimsby, JonnaGross, BenjaminGuin, RanabirGutschner, TonyHadjipanayis, AngelaHalaban, RuthHanf, BenjaminHaussler, DavidHaydu, Lauren E.Hayes, D. NeilHayward, Nicholas K.Heiman, David I.Herbert, LynnHerman, James G.Hersey, PeterHoadley, Katherine A.Hodis, EranHolt, Robert A.Hoon, Dave S. B.Hoppough, SusanHoyle, Alan P.Huang, Franklin W.Huang, MeiHuang, SharonHutter, Carolyn M.Ibbs, MatthewIype, LisaJacobsen, AndersJakrot, ValerieJanning, AlyssaJeck, William R.Jefferys, Stuart R.Jensen, Mark A.Jones, Corbin D.Jones, Steven J. M.Ju, ZhenlinKakavand, HojabrKang, HyojinKefford, Richard F.Khuri, Fadlo R.Kim, JaegilKirkwood, John M.Klode, JoachimKorkut, AnilKorski, KonstantyKrauthammer, MichaelKucherlapati, RajuKwong, Lawrence N.Kycler, WitoldLadanyi, MarcLai, Phillip H.Laird, Peter W.Lander, EricLawrence, Michael S.Lazar, Alexander J.Qazniak, RadoslawLee, DarleneLee, Jeffrey E.Lee, JunehawkLee, KennethLee, SeminLee, WilliamLeporowska, EwaLeraas, Kristen M.Li, Haiyan I.Lichtenberg, Tara M.Lichtenstein, LeeLin, PeiLing, ShiyunLiu, JiaLiu, OuidaLiu, WenbinLong, Georgina V.Lu, YilingMa, SingerMa, YussanneMackiewicz, AndrzejMahadeshwar, Harshad S.Malke, JaredMallery, DavidManikhas, Georgy M.Mann, Graham J.Marra, Marco A.Matejka, BrennaMayo, MichaelMehrabi, SousanMeng, ShaowuMeyerson, MatthewMieczkowski, Piotr A.Miller, John P.Miller, Martin L.Mills, Gordon B.Moiseenko, FedorMoore, Richard A.Morris, ScottMorrison, CarlMorton, Donald L.Moschos, StergiosMose, Lisle E.Muller, Florian L.Mungall, Andrew J.Murawa, DawidMurawa, PawelMurray, Bradley A.Nezi, LuigiNg, SamNicholson, DanaNoble, Michael S.Osunkoya, AdeboyeOwonikoko, Taofeek K.Ozenberger, Bradley A.Pagani, ElenaPaklina, Oxana V.Pantazi, AngelikiParfenov, MichaelParfitt, JeremyPark, Peter J.Park, Woong-YangParker, Joel S.Passarelli, FrancescaPenny, RobertPerou, Charles M.Pihl, Todd D.Potapova, OlgaPrieto, Victor G.Protopopov, AlexeiQuinn, Michael J.Radenbaugh, AmieRai, KunalRamalingam, Suresh S.Raman, Ayush T.Ramirez, Nilsa C.Ramirez, RicardoRao, UmaRathmell, W. KimrynRen, XiaojiaReynolds, Sheila M.Roach, JeffreyRobertson, A. GordonRoss, Merrick I.Roszik, JasonRusso, GiandomenicoSaksena, GordonSaller, CharlesSamuels, YardenaSander, ChrisSander, CindySandusky, GeorgeSantoso, NettySaul, MelissaSaw, Robyn P. M.Schadendorf, DirkSchein, Jacqueline E.Schultz, NikolausSchumacher, Steven E.Schwallier, CharlesScolyer, Richard A.Seidman, JonathanSekhar, Pedamallu ChandraSekhon, Harmanjatinder S.Senbabaoglu, YasinSeth, SahilShannon, Kerwin F.Sharpe, SamanthaSharpless, Norman E.Shaw, Kenna R. MillsShelton, CandaceShelton, TroyShen, RonglaiSheth, MargiShi, YanShiau, Carolyn J.Shmulevich, IlyaSica, Gabriel L.Simons, Janae V.Sinha, RileenSipahimalani, PayalSofia, Heidi J.Soloway, Matthew G.Song, XingzhiSougnez, CarrieSpillane, Andrew J.Spychaa, ArkadiuszStretch, Jonathan R.Stuart, JoshuaSuchorska, Wiktoria M.Sucker, AntjeSumer, S. OnurSun, YichaoSynott, MariaTabak, BarbaraTabler, Teresa R.Tam, AngelaTan, DonghuiTang, JiabinTarnuzzer, RoyTarvin, KatherineTatka, HonorataTaylor, Barry S.Teresiak, MarekThiessen, NinaThompson, John F.Thorne, LeighThorsson, VesteinnTrent, Jeffrey M.Triche, Timothy J., Jr.Tsai, Kenneth Y.Tsou, PeilingVan den Berg, David J.Van Allen, Eliezer M.Veluvolu, UmadeviVerhaak, Roeland G.Voet, DouglasVoronina, OlgaWalter, VonnWalton, Jessica S.Wan, YunhuWang, YulingWang, ZhiningWaring, ScotWatson, Ian R.Weinhold, NilsWeinstein, John N.Weisenberger, Daniel J.White, PeterWilkerson, Matthew D.Wilmott, James S.Wise, LisaWiznerowicz, MaciejWoodman, Scott E.Wu, Chang-JiunWu, Chia-ChinWu, JunyuanWu, YeXi, RuibinXu, Andrew WeiYang, DaYang, LimingYang, LixingZack, Travis I.Zen-Klusen, Jean C.Zhang, HaileiZhang, JianhuaZhang, WeiZhao, XiaobeiZhu, JingchunZhu, KelseyZimmer, LisaZmuda, ErikZou, Lihua
Issued Date
2015-06
DOI
10.1016/j.cell.2015.05.044
URI
https://scholarworks.unist.ac.kr/handle/201301/18788
Fulltext
http://www.sciencedirect.com/science/article/pii/S0092867415006340
Citation
CELL, v.161, no.7, pp.1681 - 1696
Abstract
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four sub-types based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making
Publisher
CELL PRESS
ISSN
0092-8674
Keyword
TERT PROMOTER MUTATIONSSTAGE-III MELANOMAMETASTATIC MELANOMAADJUVANT THERAPYRAF INHIBITIONNODE BIOPSYCANCERRESISTANCELANDSCAPESAFETY

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