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Author

Kim, Hajin
Single Molecule Biophysics Lab
Research Interests
  • Biophysics, Single Molecule, fluorescence Spectroscopy, biological Motors, biomolecular assembly

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Single-molecule nanometry for biological physics

Cited 8 times inthomson ciCited 7 times inthomson ci
Title
Single-molecule nanometry for biological physics
Author
Kim, HajinHa, Taekjip
Issue Date
201301
Publisher
IOP PUBLISHING LTD
Citation
REPORTS ON PROGRESS IN PHYSICS, v.76, no.1, pp. -
Abstract
Precision measurement is a hallmark of physics but the small length scale (similar to nanometer) of elementary biological components and thermal fluctuations surrounding them challenge our ability to visualize their action. Here, we highlight the recent developments in single-molecule nanometry where the position of a single fluorescent molecule can be determined with nanometer precision, reaching the limit imposed by the shot noise, and the relative motion between two molecules can be determined with similar to 0.3 nm precision at similar to 1ms time resolution, as well as how these new tools are providing fundamental insights into how motor proteins move on cellular highways. We will also discuss how interactions between three and four fluorescent molecules can be used to measure three and six coordinates, respectively, allowing us to correlate the movements of multiple components. Finally, we will discuss recent progress in combining angstrom-precision optical tweezers with single-molecule fluorescent detection, opening new windows for multi-dimensional single-molecule nanometry for biological physics
URI
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DOI
http://dx.doi.org/10.1088/0034-4885/76/1/016601
ISSN
0034-4885
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