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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 8 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.contributor.author | Lee, Dong Woog | - |
dc.contributor.author | Kristiansen, Kai | - |
dc.contributor.author | Donaldson, Stephen H., Jr. | - |
dc.contributor.author | Cadirov, Nicholas | - |
dc.contributor.author | Banquy, Xavier | - |
dc.contributor.author | Israelachvili, Jacob N. | - |
dc.date.accessioned | 2023-12-22T01:13:26Z | - |
dc.date.available | 2023-12-22T01:13:26Z | - |
dc.date.created | 2016-02-05 | - |
dc.date.issued | 2015-05 | - |
dc.description.abstract | Membrane fusion is the core process in membrane trafficking and is essential for cellular transport of proteins and other biomacromolecules. During protein-mediated membrane fusion, membrane proteins are often excluded from the membrane-membrane contact, indicating that local structural transformations in lipid domains play a major role. However, the rearrangements of lipid domains during fusion have not been thoroughly examined. Here using a newly developed Fluorescence Surface Forces Apparatus (FL-SFA), migration of liquid-disordered clusters and depletion of liquid-ordered domains at the membrane-membrane contact are imaged in real time during hemifusion of model lipid membranes, together with simultaneous force-distance and lipid membrane thickness measurements. The load and contact time-dependent hemifusion results show that the domain rearrangements decrease the energy barrier to fusion, illustrating the significance of dynamic domain transformations in membrane fusion processes. Importantly, the FL-SFA can unambiguously correlate interaction forces and in situ imaging in many dynamic interfacial systems. | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6, pp.1 - 8 | - |
dc.identifier.doi | 10.1038/ncomms8238 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.scopusid | 2-s2.0-84930226254 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/18291 | - |
dc.identifier.url | http://www.nature.com/ncomms/2015/150526/ncomms8238/full/ncomms8238.html | - |
dc.identifier.wosid | 000355538900002 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Real-time intermembrane force measurements and imaging of lipid domain morphology during hemifusion | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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