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박태주

Park, Tae Joo
Morphogenesis Lab.
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dc.citation.startPage 19377 -
dc.citation.title SCIENTIFIC REPORTS -
dc.citation.volume 6 -
dc.contributor.author Song, No-Joon -
dc.contributor.author Yun, Ui Jeong -
dc.contributor.author Yang, Sunghee -
dc.contributor.author Wu, Chunya -
dc.contributor.author Seo, Cho-Rong -
dc.contributor.author Gwon, A-Ryeong -
dc.contributor.author Baik, Sang-Ha -
dc.contributor.author Choi, Yuri -
dc.contributor.author Choi, BoYoun -
dc.contributor.author Bahn, Gahee -
dc.contributor.author Kim, Suji -
dc.contributor.author Kwon, So-Mi -
dc.contributor.author Park, Jin Su -
dc.contributor.author Baek, Seung Hyun -
dc.contributor.author Park, Tae Joo -
dc.contributor.author Yoon, Keejung -
dc.contributor.author Kim, Byung-Joon -
dc.contributor.author Mattson, Mark P. -
dc.contributor.author Lee, Sung-Joon -
dc.contributor.author Jo, Dong-Gyu -
dc.contributor.author Park, Kye Won -
dc.date.accessioned 2023-12-22T00:13:36Z -
dc.date.available 2023-12-22T00:13:36Z -
dc.date.created 2016-02-03 -
dc.date.issued 2016-01 -
dc.description.abstract Notch signaling pathways modulate various cellular processes, including cell proliferation, differentiation, adhesion, and communication. Recent studies have demonstrated that Notch1 signaling also regulates hepatic glucose production and lipid synthesis. However, the effect of Notch1 signaling on hepatic lipid oxidation has not yet been directly investigated. To define the function of Notch1 signaling in hepatic lipid metabolism, wild type mice and Notch1 deficient antisense transgenic (NAS) mice were fed a high-fat diet. High-fat diet-fed NAS mice exhibited a marked reduction in hepatic triacylglycerol accumulation compared with wild type obese mice. The improved fatty liver was associated with an increased expression of hepatic genes involved in fatty acid oxidation. However, lipogenic genes were not differentially expressed in the NAS liver, suggesting lipolytic-specific regulatory effects by Notch1 signaling. Expression of fatty acid oxidative genes and the rate of fatty acid oxidation were also increased by inhibition of Notch1 signaling in HepG2 cells. In addition, similar regulatory effects on lipid accumulation were observed in adipocytes. Taken together, these data show that inhibition of Notch1 signaling can regulate the expression of fatty acid oxidation genes and may provide therapeutic strategies in obesity-induced hepatic steatosis -
dc.identifier.bibliographicCitation SCIENTIFIC REPORTS, v.6, pp.19377 -
dc.identifier.doi 10.1038/srep19377 -
dc.identifier.issn 2045-2322 -
dc.identifier.scopusid 2-s2.0-84955266039 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/18281 -
dc.identifier.url http://www.nature.com/articles/srep19377 -
dc.identifier.wosid 000368350900002 -
dc.language 영어 -
dc.publisher NATURE PUBLISHING GROUP -
dc.title Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus ADIPOCYTE DIFFERENTIATION -
dc.subject.keywordPlus TRANSCRIPTION FACTORS -
dc.subject.keywordPlus INSULIN-RESISTANCE -
dc.subject.keywordPlus ADIPOSE-TISSUE -
dc.subject.keywordPlus PPAR-GAMMA -
dc.subject.keywordPlus INHIBITION -
dc.subject.keywordPlus OBESITY -
dc.subject.keywordPlus STEATOSIS -
dc.subject.keywordPlus PATHWAY -
dc.subject.keywordPlus DISEASE -

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