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Author

Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

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Title
Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics
Author
Sunkara, VijayaWoo, Hyun-KyungCho, Yoon-Kyoung
Keywords
NANOPARTICLE TRACKING ANALYSIS; CELL-DERIVED EXOSOMES; PANCREATIC-CANCER; CIRCULATING EXOSOMES; FLOW-CYTOMETRY; INTERCELLULAR COMMUNICATION; HUMAN PLASMA; SERUM; BIOMARKER; MICROVESICLES
Issue Date
201601
Publisher
ROYAL SOC CHEMISTRY
Citation
ANALYST, v.141, no., pp.371 - 381
Abstract
Extracellular vesicles (EVs) are cell-derived nanovesicles, present in almost all types of body fluids, which play an important role in intercellular communication and are involved in the transport of biological signals for regulating diverse cellular functions. Due to the increasing clinical interest in the role of EVs in tumor promotion, various techniques for their isolation, detection, and characterization are being developed. In this review, we present an overview of the current EV isolation and characterization methods in addition to their applications and limitations. Furthermore, EVs as the potential emerging biomarkers in cancer management and their clinical implementation are briefly discussed.
URI
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DOI
http://dx.doi.org/10.1039/C5AN01775K
ISSN
0003-2654
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