SENSORS AND ACTUATORS B-CHEMICAL, v.227, pp.504 - 514
Abstract
The development of lab-on-a-chip (LoC) systems has allowed for the successful combination of many detection methods with these systems. Surface-enhanced Raman spectroscopy (SERS) has the potential for use in rapid trace-level biological and environmental analysis because of its high sensitivity, rapid response, and fingerprint effect. With the development of nanotechnology, various active SERS substrates have been fabricated. By combining well-designed microchannels and SERS substrates, more effective and convenient SERS detecting systems have been realized. Furthermore, novel functions that were conventionally deemed impossible for normal SERS substrates have been achieved.