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Author

Kwon, H. Moo
Inflammation and Kidney Disorder Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorders, Genomic instability

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TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR gamma 2

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Title
TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPAR gamma 2
Author
Lee, Jun HoLee, Hwan HeeYe, Byeong JinLee-Kwon, WhaseonChoi, Soo YounKwon, H. Moo
Keywords
TRANSCRIPTION FACTOR NFAT5; ENHANCER-BINDING PROTEIN; PPAR-GAMMA EXPRESSION; ADIPOSE-TISSUE; ADIPOCYTE DIFFERENTIATION; METABOLICALLY HEALTHY; NUCLEAR-FACTOR; OBESITY; INFLAMMATION; RESISTANCE
Issue Date
201506
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v.5, no., pp.10937 -
Abstract
TonEBP is a key transcription factor in cellular adaptation to hypertonic stress, and also in macrophage activation. Since TonEBP is involved in inflammatory diseases such as rheumatoid arthritis and atherosclerosis, we asked whether TonEBP played a role in adipogenesis and insulin resistance. Here we report that TonEBP suppresses adipogenesis and insulin signaling by inhibiting expression of the key transcription factor PPAR gamma 2. TonEBP binds to the PPAR gamma 2 promoter and blocks the epigenetic transition of the locus which is required for the activation of the promoter. When TonEBP expression is reduced, the epigenetic transition and PPAR gamma 2 expression are markedly increased leading to enhanced adipogenesis and insulin response while inflammation is reduced. Thus, TonEBP is an independent determinant of adipose insulin sensitivity and inflammation. TonEBP is an attractive therapeutic target for insulin resistance in lieu of PPAR gamma agonists
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DOI
http://dx.doi.org/10.1038/srep10937
ISSN
2045-2322
Appears in Collections:
SLS_Journal Papers
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