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Park, Lee Soon
School of Materials Science and Engineering
Research Interests
  • Flexible OLED new materials, process and fabrication

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In Vitro Anti-Bacterial and Cytotoxic Properties of Silver-Containing Poly(L-lactide-co-glycolide) Nanofibrous Scaffolds

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Title
In Vitro Anti-Bacterial and Cytotoxic Properties of Silver-Containing Poly(L-lactide-co-glycolide) Nanofibrous Scaffolds
Author
Xing, Zhi-CaiChae, Won-PyoHuh, Man-WooPark, Lee SoonPark, Soo-YoungKwak, GiseopYoon, Keun-ByoungKang, Inn-Kyu
Keywords
Antibacterial; Cytotoxicity; Nanofiber; PLGA; Silver
Issue Date
201101
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.11, no.1, pp.61 - 65
Abstract
Electrospinning has recently emerged as a leading technique for the formation of nanofibrous structures made of organic and inorganic components. In this study, nanofibrous scaffolds were prepared by electrospining a bend solution of poly(L-lactide-co-glycolide) (PLGA) and silver nanoparticles in 1,1,1,3,3,3,-hexafluoro-2-propanol (HFIP). The resulting fibers ranged from 420 to 590 nm in diameter. To evaluate the possibility of using silver-containing PLGA as a tissue engineering scaffold, experiments on cell viability and antibacterial activity were carried out. As a result, PLGA nanofibrous scaffolds having silver nanoparticles of more than 0.5 wt% showed antibacterial effect against Staphylococcus aureus and Klebsiella pneumonia. Furthermore, silver-containing PLGA nanofibrous scaffolds showed viability, indicating their possible application in the field of tissue engineering
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DOI
http://dx.doi.org/10.1166/jnn.2011.3551
ISSN
1533-4880
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