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Park, Lee Soon
School of Materials Science and Engineering
Research Interests
  • Flexible OLED new materials, process and fabrication

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Fabrication and Characterization of Collagen-Immobilized Porous PHBV/HA Nanocomposite Scaffolds for Bone Tissue Engineering

Cited 2 times inthomson ciCited 5 times inthomson ci
Title
Fabrication and Characterization of Collagen-Immobilized Porous PHBV/HA Nanocomposite Scaffolds for Bone Tissue Engineering
Author
Baek, Jin-YoungXing, Zhi-CaiKwak, GiseopYoon, Keun-ByoungPark, Soo-YoungPark, Lee SoonKang, Inn-Kyu
Keywords
NANOFIBROUS SCAFFOLDS; SURFACE MODIFICATION; OSTEOBLAST ADHESION; CELL ATTACHMENT; IN-VITRO; COMPOSITE; HYDROXYAPATITE; PROLIFERATION; POLYESTERS; MATRICES
Issue Date
2012
Publisher
HINDAWI PUBLISHING CORPORATION
Citation
JOURNAL OF NANOMATERIALS, v.2012, no., pp.171804 -
Abstract
The porous composite scaffolds (PHBV/HA) consisting of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and hydroxyapatite (HA) were fabricated using a hot-press machine and salt-leaching. Collagen (type I) was then immobilized on the surface of the porous PHBV/HA composite scaffolds to improve tissue compatibility. The structure and morphology of the collagen-immobilized composite scaffolds (PHBV/HA/Col) were investigated using a scanning electron microscope (SEM), Fourier transform infrared (FTIR), and electron spectroscopy for chemical analysis (ESCA). The potential of the porous PHBV/HA/Col composite scaffolds for use as a bone scaffold was assessed by an experiment with osteoblast cells (MC3T3-E1) in terms of cell adhesion, proliferation, and differentiation. The results showed that the PHBV/HA/Col composite scaffolds possess better cell adhesion and significantly higher proliferation and differentiation than the PHBV/HA composite scaffolds and the PHBV scaffolds. These results suggest that the PHBV/HA/Col composite scaffolds have a high potential for use in the field of bone regeneration and tissue engineering
URI
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DOI
http://dx.doi.org/10.1155/2012/171804
ISSN
1687-4110
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