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Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis

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Damage-associated molecular patterns and their pathological relevance in diabetes mellitus

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Title
Damage-associated molecular patterns and their pathological relevance in diabetes mellitus
Author
Shin J.J.Lee, Eun KyungPark, Tae JooKim, Wook
Keywords
Damage-associated molecular pattern (DAMP); Diabetes; Inflammasome; Inflammation; Pattern recognition receptor (PRR)
Issue Date
201511
Publisher
ELSEVIER IRELAND LTD
Citation
AGEING RESEARCH REVIEWS, v.24, no., pp.66 - 76
Abstract
Diabetes, a group of metabolic and age-related diseases, is a major global health problem, the incidence of which has increased dramatically in recent decades. Type 1 diabetes mellitus (T1DM) is a complex, T cell-mediated autoimmune disease characterized by immune cell infiltration and chronic inflammation in the islets of Langerhans. Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by hyperglycemia (high blood sugar) resulting from insulin resistance and β-cell dysfunction. The involvement of inflammatory processes, such as immune cell infiltration, and chronic inflammation in the pathogenesis of diabetes is less well understood in T2DM than in T1DM. However, studies conducted in the past decade have shown a strong link between inflammation and metabolic dysfunction. They have also shown that chronic inflammation plays a key role in the pathogenesis of both T1DM and T2DM. Two immunological factors commonly contribute to the pathogenesis of diabetes: the activation of inflammasomes and the release of proinflammatory cytokines in response to damage-associated molecular patterns (DAMPs). Inflammasomes are intracellular multiprotein molecular platforms. DAMPs act as endogenous danger signals. Here, we review current research on the function(s) of inflammasomes and DAMPs and discuss their pathological relevance and therapeutic implications in diabetes. © 2015 Elsevier B.V
URI
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DOI
http://dx.doi.org/10.1016/j.arr.2015.06.004
ISSN
1568-1637
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