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DC Field | Value | Language |
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dc.citation.endPage | 837 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 827 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 67 | - |
dc.contributor.author | Lee, Young Han | - |
dc.contributor.author | Kim, Seong-Yong | - |
dc.contributor.author | Kim, Jae-Ryung | - |
dc.contributor.author | Yoh, Kyu-Tong | - |
dc.contributor.author | Baek, Suk-Hwan | - |
dc.contributor.author | Kim, Myong Jong | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kim, Jung-Hye | - |
dc.date.accessioned | 2023-12-22T12:07:18Z | - |
dc.date.available | 2023-12-22T12:07:18Z | - |
dc.date.created | 2015-08-19 | - |
dc.date.issued | 2000-07 | - |
dc.description.abstract | Oxidative stress has been implicated in a wide range of cellular damage which includes DNA oxidation, membrane lipid peroxidation, and apoptosis. In our study, we found that overexpression of PLC-beta 1 in NIH3T3 fibroblasts protected them from cell death occuring in response to oxidative stress. Cell death caused by treatment with prooxidant tert-butylhydroperoxide (TBH), H2O2, or CdCl2 was considerably suppressed in PLC-beta 1 overexpressed NIH/beta 1-14 cells in comparison to control NIH/neo cells. However, overexpression of PLC-beta 1 failed to protect the cells from toxicity by diamide or KCN. In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta 1-14 cells, while that of c-jun and GAPDH was not affected. These findings suggest that PLC-beta 1 may play a role in process that can protect cells from oxidative stress-induced cell death. (C) 2000 Elsevier Science Inc. All rights reserved | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.67, no.7, pp.827 - 837 | - |
dc.identifier.doi | 10.1016/S0024-3205(00)00677-9 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.scopusid | 2-s2.0-0034616940 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/16481 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0024320500006779 | - |
dc.identifier.wosid | 000088248400010 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Overexpression of phospholipase C beta-1 protects NIH3T3 cells from oxidative stress-induced cell death | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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