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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 618 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 615 | - |
dc.citation.title | NATURE CHEMISTRY | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Wender, Paul A. | - |
dc.contributor.author | Buschmann, Nicole | - |
dc.contributor.author | Cardin, Nate B. | - |
dc.contributor.author | Jones, Lisa R. | - |
dc.contributor.author | Kan, Cindy | - |
dc.contributor.author | Kee, Jung-Min | - |
dc.contributor.author | Kowalski, John A. | - |
dc.contributor.author | Longcore, Kate E. | - |
dc.date.accessioned | 2023-12-22T06:06:46Z | - |
dc.date.available | 2023-12-22T06:06:46Z | - |
dc.date.created | 2015-07-29 | - |
dc.date.issued | 2011-08 | - |
dc.description.abstract | The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit a remarkable range of potent biological activities. Although partial activity information is available for some natural daphnanes, little information exists for non-natural congeners or on how changes in structure affect mode of action, function, potency or selectivity. A gateway strategy designed to provide general synthetic access to natural and non-natural daphnanes is described and utilized in the synthesis of two novel members of this class. In this study, a commercially available tartrate derivative was elaborated through a key late-stage diversification intermediate into B-ring yuanhuapin analogues to initiate exploration of the structure-function relationships of this class. Protein kinase C was identified as a cellular target for these agents, and their activity against human lung and leukaemia cell lines was evaluated. The natural product and a novel non-natural analogue exhibited significant potency, but the epimeric epoxide was essentially inactive. | - |
dc.identifier.bibliographicCitation | NATURE CHEMISTRY, v.3, no.8, pp.615 - 618 | - |
dc.identifier.doi | 10.1038/nchem.1074 | - |
dc.identifier.issn | 1755-4330 | - |
dc.identifier.scopusid | 2-s2.0-79960664964 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/13399 | - |
dc.identifier.url | http://www.nature.com/nchem/journal/v3/n8/full/nchem.1074.html | - |
dc.identifier.wosid | 000292999100014 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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