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Kang, Sang Hoon
Robotics and Rehab. Engineering Lab (R2EL)
Research Interests
  • Rehabilitation Robotics & Mechatronic Tools, Biomechanics for Rehabilitation, Human Limb Impedance Estimation, Assistive and Healthcare robotics, Robust Motion/Force Control

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Characterizations of reflex and nonreflex changes in spastic multiple sclerosis

Cited 1 times inthomson ciCited 1 times inthomson ci
Title
Characterizations of reflex and nonreflex changes in spastic multiple sclerosis
Author
Zhang, Li-QunChen, KaiKang, Sang HoonSilwa, James A.Brcuce A. CohenRymer, WZWang, Liang
Keywords
Stretch reflex; Stiffness; Viscosity; Spasticity; Multiple Sclerosis; Knee
Issue Date
201407
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF NEUROSCIENCE METHODS, v.231, no., pp.3 - 8
Abstract
Background: Spasticity, an increased resistance of a limb to movement, is associated with functional limitations and a major source of disability in neurological disorders, including multiple sclerosis (MS) and stroke. Despite the clinical significance of spasticity in brain and spinal cord injuries, it is often not clear whether the spasticity is due to reflex or non-reflex changes. New method: Reflex and nonreflex properties of the human knee joint were studied in eight MS patients with spasticity and ten healthy subjects. A digitally controlled joint driving device was used to apply small-amplitude, and band-limited white-noise perturbations to the knee to manifest the reflex and nonreflex properties. The subjects were asked to maintain a steady level of background muscle torque during the perturbation. A nonlinear delay differential equation model was used to characterize the reflex and intrinsic properties of the knee in terms of phasic stretch reflex gain, tonic stretch reflex gain, joint elastic stiffness, and coefficient of viscosity. Results: It was found that joint coefficient of viscosity and tonic stretch reflex gain of the spastic MS patients were significantly lower than those of normal controls. On the other hand, spastic MS patients showed higher phasic stretch reflex gains than normal controls and a trend of increased joint stiffness. Conclusions: Simultaneous characterizations of changes in tonic and phasic reflexes and nonreflex changes in joint elastic stiffness and viscosity in neurological disorders may help us gain insight into mechanisms underlying spasticity and develop impairment-specific treatment. (C) 2014 Elsevier B.V. All rights reserved.
URI
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DOI
http://dx.doi.org/10.1016/j.jneumeth.2014.01.014
ISSN
0165-0270
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